Overproduction of large VLDL particles is driven by increased liver fat content in man

By Martin Adiels, Marja-Riitta Taskinen, C. Packard, M. Caslake, A. Soro‐Paavonen, J. Westerbacka, S. Vehkavaara, A. Häkkinen, S. Olofsson, Hannele Yki-Järvinen and 1 more. Diabetologia, 2006

707 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/c9bb4f3821a256126f2a00288fafe94bffc69ddb

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In Endocrinology, Diabetes and Metabolism

In Epidemiology

Citations in the corpus

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. (2009, background): “The Journal of Clinical Investigation http://www.jci.org Volume 119 Number 5 May 2009 1327 may be due to lipoprotein remodeling induced by increased levels of VLDL1 and mediated by cholesteryl ester transfer protein (CETP) and hepatic lipase, which results in increased concentrations of sdLDL and RL”
Pathophysiology of diabetic dyslipidaemia: where are we? (2015, background): “It has been shown that the VLDL1 production rate is correlated with insulin resistance and liver fat in patients with type 2 diabetes [57, 60].”
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “The liver can produce a range of particles varying in size from large VLDL1, medium-sized VLDL2, to LDL, depending on hepatic TG availability.(92) The rate of VLDL production is also influenced by metabolic factors, such as insulin resistance, and lipolysis and clearance of VLDL are markedly affecte”
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease (2018, background): “VLDL secretion was increased in patients with NAFLD [65, 110, 119] and liver triglyceride content was directly associated with VLDL-TG secretion rates [65, 66, 110, 119].”
Age-related changes in total and regional fat distribution. (2009, neutral): “…a series of Finnish studies report that liver fat is a significant predictor of these morbidities independent of visceral fat (SeppalaLindroos et al., 2002; Tiikkainen et al., 2002; Adiels et al., 2006), reinforcing the importance of assessing this ectopic depot in the prediction of metabolic risk.”
Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, neutral): “both hepatic and systemic lipid oxidation [13], and in VLDL-TG secretion [25,26].”
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009, background): “Moreover, data from metabolic studies conducted on human subjects (3, 4) indicate that an increase in VAT is associated with impaired glucose tolerance, insulin resistance, and increased very-low-density lipoprotein– triglyceride (VLDL-TG) secretion.”