Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

By M. Baietti, Zhe Zhang, E. Mortier, Aurélie Melchior, G. Degeest, A. Geeraerts, Y. Ivarsson, F. Depoortere, C. Coomans, E. Vermeiren and 2 more. Nature Cell Biology, 2012

1,726 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/78f62e5345c5e6cce71f5eeda00be165f76b1ee5

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Citations in the corpus

Current knowledge on exosome biogenesis and release (2017, background): “Syntenin is a multivalent soluble protein that also binds ALIX, thus establishing a link between syndecans and the ESCRT machinery [35].”
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. (2012, background): “However, increasing evidence now indicates Exosome Homogenous population with a size of 40–100 nm in diameter End of endocytic pathway, released from cells when multivesicular bodies fuse with the plasma membrane (16,103,117) Exosomal markers include CD9, CD63, Alix, flotillin-1 and Tsg101 ESCRT is ”
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (2017, positive): “We thus tried to inhibit exosome secretion by knocking down Alix or Rab27a, which are essential components of exosome biogenesis 34 and secretion 35 , respectively, using previously validated small interfering RNAs (siRNAs) 36,37 in senescent cells.”
Biological properties of extracellular vesicles and their physiological functions (2015, background): “The post-synaptic density protein, disc-large, zonulin I (PDZ) protein syntenin was reported to be necessary for the formation of MVB ILVs and, therefore, exosomes (87,88).”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, positive): “In turn, ESCRT III is recruited through programmed cell death 6 interacting protein (PDCD6IP or ALIX), and associates with the tumor susceptibility gene 101 (TSG101) as part of the ESCRT I complex (Matsuo et al. 2004; Baietti et al. 2012).”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “In reticulocytes, the transferrin receptor is generally fated for exosome secretion by interaction with Alix (69) and more recently, Alix has been described to be involved in exosome biogenesis and exosomal sorting of syndecans through its interaction with syntenin (31).”
Effect of exosomal miRNA on cancer biology and clinical applications (2018, background): “Moverover, syndecan-syntenin interact directly with the ALIX protein via Leu-Tyr-Pro-X(n)-Leu motif to support the intraluminal budding of endosomal membranes, which is an important step in exosome formation [23, 24].”
Exosomes in cancer development, metastasis, and immunity (2019, background): “For example, RAB27A and RAB27B control exosome release in HeLa cells [25], while RAB7 controls exosome release in MCF-7 breast cancer cells [27].”
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity (2013, neutral): “domains? Nat Rev Mol Cell Biol 4(12):926–937.”
Challenges and directions in studying cell–cell communication by extracellular vesicles (2022, background): “Constituents remaining within endocytic compartments for the most part end up in degradative compartments, where their catabolism could provide trophic support to the recipient cell (9).”
Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment (2018, positive): “…ﬁ ed STEAP3 (involved in exosome biogenesis 13 – 15 ), syndecan-4 (SDC4; supports budding of endosomal membranes to form multivesicular bodies 16, 17 ), and a fragment of L -aspartate oxidase (NadB; possibly boosts cellular metabolism by tuning up the citric acid cycle 18 ) as potential…”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “Baietti et al. found that syndecan-syntenin interacted directly with ALIX protein via Leu-Tyr-Pro-X(n)-Leu motif to support the intraluminal budding of endosomal membranes, which is an important step in exosome formation [35].”