Role of Rab GTPases in Membrane Traffic and Cell Physiology

By A. Hutagalung, P. Novick. Physiological Reviews, 2011

1,516 citations recorded by the source corpus.

Intracellular membrane traffic defines a complex network of pathways that connects many of the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by its own set of factors, they all contain Rab GTPases that serve as master regulators. In this review, we discuss how Rabs can regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. Some of the many regulatory functions performed by Rabs include interacting with diverse effector proteins that select cargo, promoting vesicle movement, and verifying the correct site of fusion. We describe cascade mechanisms that may define directionality in traffic and ensure that different Rabs do not overlap in the pathways that they regulate. Throughout this review we highlight how Rab dysfunction leads to a variety of disease states ranging from infectious diseases to cancer.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b0a2cfd367030470fc3ffca9486d27a7e2c5a060

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In Cell Biology

1. Y. Wong
2. R. Juliano
3. Matthias Mann
4. Daniel Ysselstein
5. D. Krainc

In Molecular Biology

1. Y. Wong
2. R. Juliano
3. Matthias Mann
4. D. Alessi
5. A. Reith
6. Daniel Ysselstein
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8. Jüergen Cox

In Physiology

1. Y. Wong
2. R. Juliano
3. Daniel Ysselstein
4. D. Krainc

Citations in the corpus

• Exosomes and their roles in immune regulation and cancer. (2015, neutral): “[98] Hutagalung AH, Novick PJ.”
• The delivery of therapeutic oligonucleotides (2016, background): “Re-segregation of the v-SNARES and t-SNARES is mediated by the ATP-dependent NSF/SNAP protein complex.”
• An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1 (2012, neutral): “Many GTPases are known to cycle on and off membranes in a nucleotide dependent manner (Hutagalung and Novick, 2011), and Rag cycling may provide a physical means to ferry mTORC1 to the lysosome.”
• Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016, background): “Model adapted and modified from (Hutagalung and Novick, 2011).”
• Mitochondria-lysosome contacts regulate mitochondrial fission via Rab7 GTP hydrolysis (2018, positive): “First, lysosomal Rab7 hydrolysis is regulated by mitochondrial TBC1D15/Rab7-GAP, providing a mechanism for mitochondria to modulate lysosomal dynamics by shutting down active Rab7, which regulates lysosomal transport, fusion and maturation 1 .”
• The endocytic recycling compartment serves as a viral factory for hepatitis E virus (2021, background): “Rab9a belongs to a class of small Rab GTPases which are effector 15 proteins promoting exchanges between the late endosome pathway and the trans 16 Golgi network [23,24], whereas CD81 and CD63 are tetraspanins found in MVB, which 17”