Rab GTPases as coordinators of vesicle traffic

By Harald A. Stenmark. Nature reviews. Molecular cell biology, 2009

3,403 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/891f4481c96529b00140e6822b7a3fb92355dfb8

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Citations in the corpus

African Swine Fever Virus: A Review (2017, background): “Rab GTPase protein family is the major regulator of the endos mal maturation pathway, wher each member of the Rab family is specifically located to a different endosomal compartment [39].”
Exosomes: extracellular organelles important in intercellular communication. (2010, background): “RAB5 localized in early endosomes mediates endocytosis and endosome fusion of clathrin-coated vesicles [43].”
Endocytosis, Signaling, and Beyond (2014, background): “RAB proteins are not only required for fusion events but they also determine the functional organization of different endosomal compartments, by flagging distinct RAB-containing membrane subdomains both in early and late endosomes (excellently reviewed by Zerial and McBride 2001; Stenmark 2009; Huot”
A molecular network for de novo generation of the apical surface and lumen (2010, methodology): “Lysates of MDCK transfected with siRNAs against Sec10 alone (1, 2, 3), in combination (pool), or with control siRNAs were blotted for Sec10 and actin as a loading control (g).”
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C (2010, background): “Because the Rab family GTPase proteins show a characteristic subcellular distribution and represent an important determinant of organelle identity (Stenmark, 2009), we address herein the question of cargo separation by studying the role of Rab proteins in exosome release in oligodendroglial cells.”
The synapsins: key actors of synapse function and plasticity. (2010, background): “Rab proteins are members of the Ras superfamily of monomeric G proteins, and are widely known for their ubiquitous role in the modulation of membrane trafficking (Stenmark, 2009).”
The LIR motif – crucial for selective autophagy (2013, background): “The Rab GTPases (a large family of monomeric, small GTPases) in their active form are spatially organized into distinct membrane regions, where they recruit effectors to regulate intracellular vesicle trafficking events (Stenmark, 2009).”
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, positive): “Here, we approached the far less studied processes governing autophagic flux by a systematic screening of Rabs, the central regulators of membrane trafficking and organellar identity in eukaryotic cells (Stenmark, 2009).”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “, 2010) or to lysosomes for degradation (Stenmark, 2009), as well as cytosolic calcium levels (Savina et al.”
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016, background): “They function as molecular switches in the tethering, docking, fusion, and motion of intracellular membranes (Stenmark, 2009; Wandinger-Ness and Zerial, 2014).”