IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

By M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Géloën, P. Even, P. Cervera, Y. Bouc. Nature, 2003

2,085 citations recorded by the source corpus.

Subfields: Aging, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/6e0fa7ae84783e047bbb5b2b81da4e109be74cd8

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Citations in the corpus

FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “Given the role of FoxO factors in the longevity of invertebrates and mounting evidence for a role of the insulin signaling pathway in mammalian longevity [55,56], we will also speculate about the possible role of FoxO factors in these tissue categories to regulate mammalian lifespan.”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “Indeed, heterozygous knockout mice for the IGF1 receptor (Igfr +/−) live longer, show a delay in the onset of pathologies, and display greater resistance to oxidative stress [175, 176], suggesting that the effects of the IGF-1 pathway on longevity are closely related to mitochondrial protection from”
The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone. (2004, result): “The search for the genes and epigenetic effects responsible for slowing or speeding the process of aging is currently very active and is producing exciting results (e.g., Gonos et al., 1998; Holzenberger et al., 2003; Collins and Sedivy, 2003; Söti et al., 2003).”
Overview of caloric restriction and ageing. (2005, background): “Female mice heterozygous for the disruption of the IGF-1 receptor gene also have an extended life span and increased resistance to oxidative stress (Holzenberger et al., 2003).”
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span (2004, background): “Indeed, PTEN-null cells are sensitive to inhibition of TOR by a rapamycin derivative (CCI-779) (Neshat et al., 2001; Podsypanina et al., 2001), which is currently in phase II clinical trials as an anticancer agent (Huang and Houghton, 2003).”
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “In mammals, spontaneous mutations that result in growth hormone (GH) deficiency, such as the Prop-1 and Pit-1 dwarf mice [14,15], or targeted mutations in the insulin-like growth factor 1 (IGF-1) receptor gene [16] or the insulin receptor substrate 1 (IRS1) can result in increased lifespan [17], sug”
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. (2006, background): “The relatively long lifespan of mice, which live at least 2.5 years [11], is a hurdle for life-long pharmacological trials.”
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “Mutations that diminish insulin-like signaling also increase life span and stress resistance in Drosophila and mice (Clancy et al., 2001; Holzenberger et al., 2003), suggesting that the effect of this pathway on longevity is conserved.”
Extending life span by increasing oxidative stress. (2011, positive): “preventing neurodegenerative processes [74,75].”