The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

By Kailiang Jia, Di Chen, D. Riddle. Development, 2004

766 citations recorded by the source corpus.

Subfields: Complementary and Manual Therapy, General Health Professions, Speech and Hearing

View Paper: https://www.semanticscholar.org/paper/6f773f2b7eeab3f708e9395eb7c2d7daffeb8276

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Citations in the corpus

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “Involvement of mTOR in regulation of aging was suggested by evidence that impairment of mTOR activity in flies (9), worms (10,11), and yeast (12) could lead to life span extension, and by observations that mTOR function was lower in several mouse models of slow aging, including data on dwarf mice (1”
mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “This was first observed through studies in the nematode C. elegans, which found that reduced expression of the homologs of mTOR (ceTOR, formerly let-363) or Raptor (daf-15) extend life span (Vellai et al., 2003; Jia et al., 2004).”
MYC, Metabolism, and Cancer. (2015, background): “These TOR-regulated adaptive mechanisms are recapitulated in the higher organism Caenorhabditis elegans, which can go into the dormant “dauer” state with severe nutrient deprivation (79, 80).”
The plasticity of aging: insights from long-lived mutants. (2005, neutral): “(Jia et al., 2004; Kapahi et al., 2004; Ramsey et al., 2002).”
mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “This was first observed through studies in the nematode C. elegans, which found that reduced expression of the homologs of mTOR (ceTOR, formerly let-363) or Raptor (daf-15) extend lifespan (Vellai et al., 2003; Jia et al., 2004).”
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “168 Later on, other genetic screening studies also noticed that reduced mTOR signaling enhanced the life span of the drosophila, yeast, and murine models.”
LKB1 and AMPK control of mTOR signalling and growth (2009, background): “Conversely, suppression of TOR promotes lifespan extension in C. elegans (Vellai et al. 2003, Jia et al. 2004, Kapahi et al. 2004).”
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “TOR is indeed dedicated to controlling cell growth, but what is this target and how does it control cell growth?”
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (2012, background): “It has been reported that daf-16 is needed for life span extensions associated with daf-15 heterozygosity or raga-1 mutation (Jia et al., 2004; Schreiber et al., 2010), but several considerations made it unclear how to interpret those findings: these mutations impair larval development, DAF-16…”