Overview of caloric restriction and ageing.

By E. Masoro. Mechanisms of Ageing and Development, 2005

1,085 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/03062bfc84075f2a3611b74ce6cb054114d6f324

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Nir Barzilai
2. Mark P. Mattson
3. A. Brunet
4. Stephen J. Simpson
5. J. Villén
6. Steven P. Gygi
7. David Raubenheimer
8. E. L. Greer

In Endocrine and Autonomic Systems

1. David Raubenheimer
2. Stephen J. Simpson
3. Mark P. Mattson
4. J. Villén
5. Nir Barzilai
6. Steven P. Gygi
7. E. L. Greer
8. V. Longo

In Physiology

1. Mark P. Mattson
2. Nir Barzilai
3. V. Longo
4. David Raubenheimer
5. Stephen J. Simpson
6. Steven P. Gygi
7. E. L. Greer
8. A. Brunet

Citations in the corpus

• Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 (2010, background): “longevity and healthy aging, often by mechanisms that appear conserved across phyla [13,23,24].”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Several hypotheses have been proposed to explain the mechanisms by which CR functions to produce these beneficial effects, but a decrease in energy expenditure, along with concomitant reductions in ROS production and oxidative damage, appear to be key components in many studies (92, 129, 157, 245).”
• The nature of nutrition: a unifying framework (2011, background): “Themost widely accepted view is that eating fewer calories (called ‘caloric restriction’ or ‘calorie restriction’) is the reason for living longer, whatever the source of those calories might be, whether protein, carbohydrate or fat (Weindruch andWalford 1988; Masoro 2005; Everitt et al. 2010).”
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “Dietary restriction (DR)—restriction in food intake without malnutrition—increases both the mean and maximal lifespan in a wide range of species [1].”
• The Critical Role of Metabolic Pathways in Aging (2012, background): “Biological characteristics of animals exposed to CR include numerous other changes in the transcriptome, metabolome, and proteome, as well as increases in stress hormones (corticosterone or cortisol depending on the species) (40).”
• Fasting: Molecular Mechanisms and Clinical Applications (2014, methodology): “The remarkable effects of the typical 20%–40%CR on aging and diseases in mice and rats are often viewed as responses evolved in mammals to adapt to periods of limited availability of food (Fontana and Klein, 2007; Fontana et al., 2010; Masoro, 2005; Weindruch andWalford, 1988).”