TRPV3 is a calcium-permeable temperature-sensitive cation channel

By Haoxing Xu, I. S. Ramsey, S. A. Kotecha, M. Moran, J. Chong, Deborah Lawson, P. Ge, Jeremiah Lilly, Inmaculada Silos-Santiago, Yu Xie and 3 more. Nature, 2002

891 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/6c8c4783a8531eb2604a0c75ed45ea199fb95ff3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Ardem Patapoutian
2. Clifford J. Woolf
3. R. Ji
4. B. Nilius
5. A. Dhaka
6. Taryn J. Earley
7. Veena Viswanath
8. T. Voets

In Nutrition and Dietetics

1. B. Nilius
2. Ardem Patapoutian
3. Veena Viswanath
4. T. Voets
5. Clifford J. Woolf
6. S. R. Eid
7. Taryn J. Earley
8. G. M. Story

In Sensory Systems

1. Ardem Patapoutian
2. Clifford J. Woolf
3. B. Nilius
4. R. Ji
5. A. Dhaka
6. D. Julius
7. D. Clapham
8. T. Voets

Citations in the corpus

• TRP channels as cellular sensors (2003, neutral): “Increased temperature also activates TRPV3 (>31 °C”
• The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels (2004, background): “Four TRP channels belonging to the TRPV subfamily are activated by heating, with characteristic activation temperatures ranging from warm temperatures (> 25 °C for TRPV4; >31 °C for TRPV3”
• An introduction to TRP channels. (2006, background): “Expressed TRPV3 also mediates a weakly Ca2+-selective cationic conductance in response to non-noxious heat, 2-APB, or camphor (86, 92, 93).”
• ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. (2003, background): “…activated at various heat thresholds, rang-Foundation San Diego, California 92121 ing from 33 C (warm) for TRPV3 to 55 C (high-threshold noxious heat) for TRPV2/VRL1 (Peier et al., 2002b; Smith3 Novartis Institute for Medical Sciences London et al., 2002; Xu et al., 2002; Caterina et al., 1999).”
• TRP Channels (2012, neutral): “The single channel conductance of TRPV3 is between 172 and 190 pS (491).”
• Trp ion channels and temperature sensation. (2006, background): “Other studies looking at expression in monkey and human tissue found TRPV3 mRNA and protein in sensory neurons, respectively (Smith et al. 2002, Xu et al. 2002).”
• p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. (2002, positive): “The ERK (extracellular signal-regulated kinase) member of the Although a null mutation of TRPV1 has minimal effects on basal heat threshold, presumably reflecting a contriMAPK family is activated by neuronal activity and is involved in neuronal plasticity, including long-term po- bution of the TRP h”
• painless, a Drosophila gene essential for nociception. (2003, background): “TRPV1 are expressed in dorsal root ganglia and are activated by heat in heterologous expression systemsRecordings from wild-type larval nerves identified neurons that initiated strong spiking above 38 C, and (Peier et al., 2002; Smith et al., 2002; Xu et al., 2002).”