Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.
By A. Satoh, Cynthia S. Brace, N. Rensing, P. Cliften, D. Wozniak, E. Herzog, Kelvin A. Yamada, S. Imai. Cell Metabolism, 2013
706 citations recorded by the source corpus.
Subfields: Aging, Geriatrics and Gerontology, Physiology
View Paper: https://www.semanticscholar.org/paper/5658512b7a6f9c2f1896ef797646af849c6cbf05
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Citations in the corpus
- SIRT1 and other sirtuins in Metabolism (2013, background): “Moreover, transgenic over-expression of SIRT1 in the DMH and LH slows aging and extends life span in both males and females [13].”
- NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “…sirtuin activation in mammals delays the onset of agerelated degenerative processes (Herranz et al., 2010; Kanfi et al., 2012; Pearson et al., 2008; Satoh et al., 2013) and that defective sirtuin activity impairs some of themetabolic and physiological benefits triggered by CR (Boily et al., 2008;…”
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013, background): “Indeed, increased expression of neuronal SIRT1 extends mouse lifespan (Satoh et al., 2013), though its role in aging in lower organisms has been challenged (Burnett et al., 2011).”
- Sirt1 and the Mitochondria (2016, background): “Cells 2016; 39(2): 87-95 http://dx.doi.org/10.14348/molcells.2016.2318”
- Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2016, neutral): “One would also suspect that some of the anti-aging effects of NMN administration might be modified by the function of SIRT1 in the brain, particularly in the hypothalamus (Satoh et al., 2013; Yoon et al., 2015).”
- NAD+ and Sirtuins in Aging and Disease (2014, background): “Most recently, it has been demonstrated that increasing SIRT1 specifically in the brain, particularly in the dorsomedial and lateral hypothalamic nuclei, delays aging and extends lifespan in both male and female mice (20).”
- NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “For instance, both brain-specific or whole-body SIRT1-overexpressing transgenic mice exhibit a slowed aging and a prolonged lifespan.(347,348)”