NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus
By C. Cantó, Keir J. Menzies, Johan Auwerx. Cell Metabolism, 2015
1,456 citations recorded by the source corpus.
NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD+ metabolism revived interest in NAD+ boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD+ metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
Subfields: Geriatrics and Gerontology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/b2143b2607d844771cb06699075d8df415a31d77
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Geriatrics and Gerontology
In Oncology
In Physiology
- Jun Yoshino
- S. Imai
- Joseph A. Baur
- Ruisheng Wang
- Joseph Loscalzo
- Diane E. Handy
- Wusheng Xiao
- D. Sinclair
Citations in the corpus
- NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism (2018, background): “As mentioned earlier, the mitochondrial inner membrane is impermeable to NADP(H) (24, 102, 141).”
- NAD+ intermediates: The biology and therapeutic potential of NMN and NR (2017, positive): “In addition, accumulating evidence suggests that NAD+ levels decline with age at a systemic level in diverse organisms, including rodents and humans, contributing to the development of many age-associated pathophysiologies (Canto et al., 2015; Imai and Guarente, 2014; Verdin, 2015).”
- Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2016, positive): “…(PARPs), and CD38/157 ectoenzymes, play critical roles in many biological processes including metabolism, inflammation, and stress and damage response (Cantó et al., 2015; Imai and Guarente, 2014), such global decreases in NAD+ availability could result in serious physiological decline over age.”