SIRT1 and other sirtuins in Metabolism

By Hung-Chun Chang, L. Guarente. Trends in endocrinology and metabolism, 2013

1,078 citations recorded by the source corpus.

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, accumulating evidence has indicated that sirtuins are not only important energy status sensors but also protect cells against metabolic stresses. Sirtuins regulate the aging process and are themselves regulated by diet and environmental stress. The versatile functions of sirtuins and more specifically SIRT1 are supported by their diverse cellular location allowing cells to sense changes in energy levels in the nucleus, cytoplasm and mitochondrion. SIRT1 plays a critical role in metabolic health by deacetylating many target proteins in numerous tissues, including liver, muscle, adipose tissue, heart and endothelium. This sirtuin also exerts important systemic effects via the hypothalamus. This review will cover these topics and suggest that strategies to maintain sirtuin activity may be on the horizon to forestall diseases of aging.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/ae95b9b1b550f485004d630a3637493b4dd0a1cb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Geriatrics and Gerontology

Guido Kroemer

In Physiology

Citations in the corpus

Acetyl coenzyme A: a central metabolite and second messenger. (2015, background): “This applies, for instance, to EP300 as well as to the deacetylase SIRT1, both of which shuttle between the nucleus and the cytosol (Chang and Guarente, 2014).”