Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis

By Elodie Drapeau, W. Mayo, C. Aurousseau, M. Le Moal, P. Piazza, D. Abrous. Proceedings of the National Academy of Sciences of the United States of America, 2003

677 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/64f309ce530e52477ab27a982e9015f6edf312c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Fred H. Gage
2. Wei Deng
3. Hongjun Song
4. E. Gould
5. J. Snyder
6. D. Abrous
7. Chunmei Zhao
8. J. Martin Wojtowicz

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Wei Deng
4. Guo-li Ming
5. E. Gould
6. B. Leuner
7. James Bradley Aimone
8. Chunmei Zhao

In Neurology

1. Fred H. Gage
2. Wei Deng
3. Hongjun Song
4. E. Gould
5. Chunmei Zhao
6. H. van Praag
7. B. Leuner
8. J. Snyder

Citations in the corpus

• GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. (2005, positive): “, 2002), which may underpin the modulation of cognitive brain functions (Shors et al., 2001; Feng et al., 2001; Drapeau et al., 2003).”
• Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, methodology): “Free-floating sections (50 lm) were processed in a standard immunohistochemical procedure in order to visualized BrdU (1/200; Dako, http://www.dako.com), IdU (1/1,000, BD PharMingen #347580; BD Biosciences, http://www.bdbiosciences.com), CldU (1/1,000; Accurate Chemical and Scientific Corporation, h”
• Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats (2007, methodology): “For BrdU and Ki67 labeling, one in 10 free-floating sections was processed according to a standard immunohistochemical procedure (Drapeau et al., 2003; Montaron et al., 2006) using a mouse anti-BrdU monoclonal antibody or a mouse anti-Ki-67antibody (both at 1:100; Dako, Glostrup, Denmark)…”
• Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005, background): “Previous studies have suggested that cognitive decline in aging may be attributable to decreased dentate gyrus neurogenesis (Kempermann et al., 1998; Drapeau et al., 2003; Merrill et al., 2003; Bizon et al., 2004).”
• RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “, 2009) and that impaired neurogenesis may contribute to hippocampal dysfunction observed in neuropsychiatric diseases such as cognitive decline during aging (Kuhn et al., 1996; Drapeau et al., 2003), anxiety and depression (Bergami et al.”
• Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus (2005, methodology): “This time was required as in aged rats cell proliferation is greatly reduced and multiple BrdU injections are necessary to label a sufficient number of cells (Drapeau et al., 2003).”
• New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, background): “observations include the correlation between hippocampal neurogenesis and acquisition of new information observed in inbred strains of mice (Kempermann & Gage, 2002) or aged rats with differential learning performance (Drapeau et al., 2003), or the finding that increased neurogenesis produced by phy”
• Neurogenesis in the Adult Hippocampus. (2015, background): “A positive correlation between hippocampal neurogenesis and learning-related parameters in the Morris water maze has been found at least in some studies (Kempermann and Gage 2002; Drapeau et al. 2003).”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “Performance in a hippocampus-dependent spatial learning task correlates with the number of new neurons in aged rats (Drapeau et al, 2003), suggesting a functional contribution to learning.”
• Neurogenesis and Exercise: Past and Future Directions (2008, background): “2007) and has been associated with cognitive deficits (Drapeau et al. 2003; see however Bizon and Gallagher 2003; Merrill et al. 2003).”
• The Aging Cortical Synapse: Hallmarks and Implications for Cognitive Decline (2012, neutral): “Despite a significant age-related reduction in neurogenesis in the dentate gyrus, the birth rate of new neurons was uncorrelated with spatial learning abilit”
• Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “Furthermore, decreases in adult neurogenesis in the dentate gyrus start emerging at middle age and continue throughout the aging process (Drapeau et al., 2003).”
• Stems cells and the pathways to aging and cancer. (2008, background): “, 1996), which is associated with age-related loss of cognitive ability (Drapeau et al., 2003).”
• Structural Plasticity and Hippocampal Function (2010, background): “These include stress, increased levels of circulating glucocorticoids, and aging (Drapeau et al. 2003, Montaron et al. 2006).”
• Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, background): “In this regard, it has been shown that, in aged rats, spatial memory at least can be predicted by levels of hippocampal neurogenesis (Drapeau et al., 2003).”