Inhibition of neurogenesis interferes with hippocampus‐dependent memory function

By Gordon Winocur, J. Martin Wojtowicz, M. Sekeres, J. Snyder, Sabrina Wang. 2006

611 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Deficits in this task have been repeatedly observed in rodents in which neurogenesis was almost completely eliminated by irradiatio”
A model of hippocampal neurogenesis in memory and mood disorders. (2007, background): “We can do this by considering the hippocampus-dependent behavioural functions and the deficits that are specifically associated with a loss of neurogenesis.”
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s. (2017, background): “Cognitive impairments are the most described functional defects observed in mice and humans following WBI [4,16].”
Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory (2009, background): “, 10 days after BrdU injections), we found more BrdU-labeled cells in the DG of both Spatial PF and Swim animals compared with Cage control mice [F(2,15) 6.”
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus (2006, background): “…in defined brain regions such as the DG of the hippocampus, adult neurogenesis, the birth and growth of new neurons, is another form of neural plasticity that may contribute to hippocampaldependent memory function (Shors et al., 2001; Bruel- Jungerman et al., 2005; Winocur et al., 2006).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “For example, classical conditioning of context fear has been reported to be impaired after blocking neurogenesis (Saxe et al. 2006; Winocur et al. 2006; Imayoshi et al. 2008; Wojtowicz et al. 2008), whereas contextual fear conditioning has also been reported to be intact after blocking hippocampal…”
The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, positive): “Recent ablation studies have implicated adult-born neurons in several hippocampal-dependent behaviors including spatial learning (Snyder et al., 2005), contextual fear conditioning (Saxe et al., 2006; Winocur et al., 2006), and depressive behaviors (Santarelli et al., 2003).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “…of studies have shown that adult hippocampal neurogenesis is required for different hippocampaldependent behavioral responses including the effects of chronic antidepressant treatments (Santarelli et al., 2003) and memory function (Snyder et al., 2005; Saxe et al., 2006; Winocur et al., 2006).”
Adult hippocampal neurogenesis in depression (2007, background): “Reducing or blocking hippocampal neurogenesis in rats or mice affects hippocampus-dependent forms of fear conditionin”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, positive): “, 2006) and contribute to hippocampus-dependent behaviors (Shors et al., 2001, 2002; Santarelli et al., 2003; Snyder et al., 2005; Saxe et al., 2006, 2007; Winocur et al., 2006).”