Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
By Christopher Pittenger, R. Duman. Neuropsychopharmacology, 2008
1,810 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience
View Paper: https://www.semanticscholar.org/paper/a91beda310b37ed32814831bac8b3c11f720807f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Developmental Neuroscience
- Bruce S. McEwen
- G. Agam
- Peter J. Gianaros
- M. Popoli
- G. Sanacora
- G. Treccani
- R. Belmaker
- J. Wingfield
Citations in the corpus
- Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “…it is increasingly appreciated that impairments in synaptic plasticity render a given neural circuit less flexible and adaptable and may represent a primary substrate underlying the transition of chronic stress into mental illness (Calabrese et al, 2009; McEwen, 2012a; Pittenger and Duman, 2008).”
- Towards a glutamate hypothesis of depression (2011, background): “…inducing dendritic remodeling, synaptic spine reductions, glial loss, and possibly volumetric reductions resembling those observed in depressed patients (Gorman and Docherty, 2010; Holmes and Wellman, 2009; McEwen, 2005; Musazzi et al., 2011; Pittenger and Duman, 2008; Shansky and Morrison, 2009).”
- Major depressive disorder. (2008, positive): “hippocampus by chronic antidepressant treatment [2,53,68,69].”
- Psychedelics Promote Structural and Functional Neural Plasticity (2018, background): “A preponderance of evidence from a combination of human imaging, postmortem studies, and animal models suggests that atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders and is precipitated and/or exacerbated by stress (Arnsten”
- Stress- and Allostasis-Induced Brain Plasticity (2011, positive): “Moreover, there is increasing support for the notion that targeting the plasticity of the hippocampus in depression and mood disorders may underpin pharmacological and nonpharmacological treatment efficacy (17, 18).”