GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells.

By Yusuke Tozuka, S. Fukuda, Takashi Namba, T. Seki, T. Hisatsune. 2005

746 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the adult SGZ, local interneurons release GABA, which in turn regulates cell proliferation as well as maturation, dendritic development, and synaptic integration of newborn neurons (Ge et al., 2006; Tozuka et al., 2005).”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “…directly depolarizes type 2 progenitors in the adult hippocampus, which results in calcium ion influx and increased expression of the neuronal differentiation factor NeuroD, suggesting that direct GABAergic input promotes the differentiation of type 2 hippocampal progenitors (Tozuka et al., 2005).”
Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus (2009, background): “In vivo, excitation–neurogenesis coupling is likely achieved by depolarizing GABAergic input (Tozuka et al., 2005), because hippocampal progenitors and newborn neurons first receive depolarizing GABAergic input before glutamatergic synapses are established (Espósito et al.”
Adult neurogenesis and the olfactory system. (2009, background): “Transit-amplifying cells in the DG receive GABAergic inputs, which cause depolarization and an increase in intracellular Ca2+, and promote neuronal differentiation (Tozuka et al., 2005).”
Distinct Determinants of Sparse Activation during Granule Cell Maturation (2013, background): “GABAergic mechanisms also have important trophic functions in adult neurogenesis, promoting morphological and synaptic integration of newborn GCs that are depolarized by GABA due to elevated intracellular [Cl ] (Tozuka et al., 2005; Ge et al., 2006; Dieni et al., 2012; Chancey et al., 2013).”
Seizures Accelerate Functional Integration of Adult-Generated Granule Cells (2006, positive): “Depolarizing GABAergic input to neural progenitors (Tozuka et al., 2005; Wang et al., 2005) could thus contribute to seizure-induced enhanced neurogenesis.”
Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus (2006, background): “…modulation of granule cell maturation could result from direct GABAergic depolarization (Esposito et al., 2005; Overstreet-Wadiche et al., 2005; Tozuka et al., 2005; Wang et al., 2005; Ge et al., 2006), indirect depolarization via extracellular K accumulation (Deisseroth et al., 2004), or by…”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Previous work has identified an important role of GABAergic input (Tozuka et al., 2005; S. Ge et al., 2006; Overstreet-Wadiche et al., 2006) and NMDA-receptor-mediated synaptic input (Tashiro et al., 2006b) on the differentiation, morphological maturation, and integration of young neurons into the…”
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, background): “It is assumed that this decay, and with it the level of detection, are different between endogenous protein and reporter product but very few studies have actually addressed this issue (Corish and Tyler-Smith, 1999; Mellodew et al., 2004; Verkhusha et al., 2003).”
Neurogenesis in the Adult Hippocampus. (2015, background): “On the level of type 2 cells, the developing cells also receive first synaptic input, which is GABAergic (Tozuka et al. 2005; Wang et al. 2005).”
Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, methodology): “Based on an established protocol (Tozuka et al., 2005), we gave 6-week-old WT and Bdnf mice phenobarbital systemically once a day for 3 d, and on the fourth day administered BrdU.”
The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus (2008, positive): “In addition, signaling by the chemokine stromal cell-derived factor-1 (SDF-1; also known as CXCL12) via its receptor CXC chemokine receptor 4 (CXCR4) has been shown to be of great importance in the development of many tissues including the nervous system (Tran and Miller, 2003).”
Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “gic input [46] prompted us to search for evidence of GAD65positive terminals on DCX+ cells.”
FAD-linked human Presenilin 1 variants impair environmental enrichment-induced hippocampal neural progenitor cell proliferation and differentiation in a non-cell-autonomous manner (2008, neutral): “As an example, Wen et al. (2004) reported that enriched mice expressing the PS1M117L variant exhibited elevated levels of cell proliferation in the DG, compared to PS1hWT mice (Wen et al.”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, positive): “At early stages of cell development, activation of GABAA receptors by ambient GABA regulates neuronal differentiation of hippocampal progenitor cells (Tozuka et al., 2005) and dendritic growth of newborn GCs in the adult brain (Ge et al.”