Does the ribosome translate cancer?

By D. Ruggero, P. Pandolfi. Nature Reviews. Cancer, 2003

968 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/64d13eb3897871a6b9810f8654b0f36a103c8dd3

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In Molecular Biology

Citations in the corpus

Regulation of cap-dependent translation by eIF4E inhibitory proteins (2005, background): “Consistent with the oncogenic potential of eIF4E, several studies have shown that human tumours express abnormally high levels of this protei”
Integrative molecular concept modeling of prostate cancer progression (2007, background): “As ETS targets are overexpressed in PIN, possibly through subtle, direct dysregulation of ETS family members or through a distinct genetic lesion with overlapping targets (such as MYC or PTEN , which can regulate protein biosynthesi”
Upstream and downstream of mTOR. (2004, background): “…oncogenic potential of eIF4E and eIF4G, there is ample evidence that they and other translation initiation factors (such as eIF4A and several subunits of eIF3) are overexpressed in human tumors (for reviews, see De Benedetti and Harris 1999; Hershey and Miyamoto 2000; Ruggero and Pandolfi 2003).”
Shifts in growth strategies reflect tradeoffs in cellular economics (2009, background): “An apparent shift to inefficient metabolism is also observed when expressing recombinant protein in E. coli (Sandén et al, 2003).”
A mechanistic link between cellular trade-offs, gene expression and growth (2015, positive): “Third, disregulated biogenesis of ribosomes has been suggested as a driver for cancer development [55], and our model may help select, for example, therapeutic targets in the translation machinery.”
The complexity of p53 stabilization and activation (2006, background): “Since p53 represses Pol1 transcription on the rRNA promoter, this may represent another level of cell cycle control by p53 in response to stress.(17) Stabilization and activation of p53 is also achieved in response to oncogenic stimuli.”
Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes. (2017, background): “A recent revival is the interest in inherent mechanisms related with cancer for which the human ribosome appears to be a promising target [34,58].”
Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin (2010, background): “304-annotation-218">homoharringtonine , two small-molecule inhibitors of translation, have advanced to clinical trial”
Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway (2003, background): “Lastly, both Rb family proteins and p53 have been reported to negatively regulate Pol I-dependent rRNA transcription (recently reviewed by Ruggero and Pandolfi) (36).”
MYC as a regulator of ribosome biogenesis and protein synthesis (2010, background): “The increased expression of ribosomal proteins has also been associated with increased proliferation and growt”
MYC activation is a hallmark of cancer initiation and maintenance. (2014, background): “Collectively, these results suggest that a global shift in protein biogenesis is an important feature of how MYC suppression results in tumor regression (Ruggero and Pandolfi 2003).”
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. (2004, background): “Many additional connections between p53 and the nucleolus have been unearthed (Ruggero and Pandolfi 2003).”
LKB1 and AMPK control of mTOR signalling and growth (2009, background): “Furthermore, eIF4E is an oncogene upregulated in a number of cancers (Ruggero & Pandolfi 2003), and eIF4E overexpression has been shown to be sufficient to promote rapamycin-resistant growth of tumours (Wendel et al. 2006) and promote increased cyclin D1 (Averous et al. 2008).”
In brief (2011, neutral): “Several findings suggest that upregulation of the protein synthesis machinery contributes to the development of cancer and other diseases (Ruggero and Pandolfi, 2003).”
The multifunctional nucleolus (2007, background): “In addition to dyskerin, several other proto-oncogenes and tumour-suppressor proteins affect the production of ribosome”
mTOR, translation initiation and cancer (2006, background): “…et al., 2005; Stephens et al., 2005; Petroulakis et al., 2006) (Figure 2). mTOR promotes the phosphorylation and activation of S6K and the hierarchial phosphorylation the 4E-BPs (Gingras et al., 2001; Jacinto and Hall, 2003; Kim et al., 2003; Ruggero and Pandolfi, 2003; Kim and Sabatini, 2004).”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “The translational machinery is tightly regulated in mammalian cells, and this is in part mediated by the controlled translation of RPs (Ruggero and Pandolfi, 2003).”