The multifunctional nucleolus

By François-Michel Boisvert, S. Koningsbruggen, J. Navascués, Angus I. Lamond. Nature reviews. Molecular cell biology, 2007

1,547 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/05d142593967d85dff6c64483353f6cc38d34e99

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Citations in the corpus

Biogenesis and Function of Nuclear Bodies (2011, background): “The tripartite architecture of the nucleolus reflects its function as rDNAs are localized in the FCs; transcription occurs on the border between the FCs and the DFC; fibrillarin and small nucleolar ribonucleoproteins (snoRNPs) are in the DFC where pre-rRNAs are processed; and pre-ribosomal subunits ”
The Nucleolus under Stress (2010, neutral): “Both the FC and the DFC are enclosed by the GC, where preribosome subunit assembly takes place (reviewed in Boisvert et al., 2007; Sirri et al., 2008) (Figure 1B).”
A census of human RNA-binding proteins (2014, background): “, 2011) ribosomal RNA (rRNA) ~1205070 Structural component of ribosomes (Boisvert et al., 2007; Ciganda and Williams, 2011; Granneman and Baserga, 2004; Woolford and Baserga, 2013) small nuclear RNA (snRNA) ~150 snRNAs U1, U2, U,4, U5 , U6, U12, U4atac, U6atac are core components of the spliceosome;”
Liquid phase condensation in cell physiology and disease (2017, background): “The nucleolus functions in part as a reaction crucible for rRNA biogenesis, but it has long been thought to have additional functional roles, particularly in the cell cycle and stress-dependent sequestration of key signaling molecules (74).”
Liquid-liquid phase separation in biology. (2014, background): “Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.”
Coexisting liquid phases underlie nucleolar sub-compartments (2016, positive): “What are the functional implications of liquid phase immiscibility and surface-tension driven subcompartmentalization of the nucleolus? The most important nucleolar function is ribosome biogenesis (Boisvert et al., 2007), which involves the coordinated modification and assembly of rRNA through multi”
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (2009, neutral): “Centromeres cluster around nucleoli throughout the cell cycle (Figures S4A and S4B); however, during G1, NPM1 was also found in extranucleolar foci following the disassembly of the nucleoli during mitosis (Boisvert et al., 2007).”
Oncogenic Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms (2011, neutral): “Whether these nucleolar mechanisms play a role in pri-miRNA regulation remains to be determined (Boisvert et al., 2007; Matera et al., 2007).”
Phase separation in biology; functional organization of a higher order (2016, background): “This ability to respond to environmental cues may represent the mechanistic basis for the involvement of the membrane-less organelles discussed herein in stress sensing [2, 4, 9, 11, 13, 15].”