MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation.

By U. A. Ørom, F. Nielsen, A. Lund. Molecules and Cells, 2008

1,448 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ee75197fa68f69ed0eb24716872542c4e212d6e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

MicroRNA (miRNA) in cancer (2015, background): “Recent studies have suggested that miRNAs binds to 5′UTR or open reading frame (ORF) of the target mRNA [18,19].”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, background): “However, miRNAs are believed to predominantly act on 30UTRs (Bartel, 2009), with relatively few reports providing experimental evidence for miRNA-binding to individual 50UTRs or CDS (Easow et al., 2007; Forman et al., 2008; Lytle et al., 2007; Orom et al., 2008; Tay et al., 2008).”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “(12) found that miR-10a interacts with the 5′ UTR of many mRNAs encoding ribosomal proteins and is responsible for increased translation of these mRNAs in response to stress or nutrient shortage.”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, neutral): “Additional ways in which miRNAs activate genes include their binding to the CDS or the 5′ UTR of mRNAs 35,36 .”
starBase: a database for exploring microRNA–mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data (2010, background): “…numerous CLIP-Seq clusters were not located within the 3 0 -UTR of the gene, indicating that the miRNA may bind to the coding region and the 5 0 -UTR, as has been reported for ribosomal protein regulation by mir-10a (48) and Nanog, Oct4 and Sox2 regulation by miR-134, miR-296 and miR-470 (49).”
Tools for Sequence-Based miRNA Target Prediction: What to Choose? (2016, background): “These elements are the 5′ UTR [69,70], the open reading frames (ORFs) [71,72] and the coding sequence (CDS) for mRNAs [73], which have been included in the search of certain miRNA target prediction tools.”
An overview of microRNAs (2015, background): “An alternative approach is isolation of specific biotinylated miRNAs followed by target identification[109, 110].”
Revisiting the principles of microRNA target recognition and mode of action (2009, background): “pl?acc=MI0000266">miR-10a showed that it targets ribosomal protein transcripts via non-seed sites in the 5′ UT”