MYC as a regulator of ribosome biogenesis and protein synthesis

By Jan van Riggelen, Alper Yetil, Dean W. Felsher. Nature Reviews. Cancer, 2010

925 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/edfb5822de1ac7e66e7616419cdad28561ac41e1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Aviv Regev
2. C. V. Dang
3. Dean W. Felsher
4. Yulin Li
5. Meital Gabay
6. Amir Goren
7. Runan Yao
8. Hua Lu

Citations in the corpus

• MYC, metabolism, cell growth, and tumorigenesis. (2013, background): “This view is compatible with the observations that MYC is tightly linked to the generation of ribosomes through its ability to activate genes involved in ribosome biogenesis (van Riggelen et al. 2010).”
• Ribosomal proteins: functions beyond the ribosome. (2015, background): “By contrast, oncogenic signals often promote cell growth and proliferation by boosting ribosome biogenesis and global protein synthesis (van Riggelen et al., 2010).”
• Transcriptional Amplification in Tumor Cells with Elevated c-Myc (2012, neutral): “…Hurlin and Dezfouli, 2004; Kuttler and Mai, 2006; Lin et al., 2009; Meyer and Penn, 2008; Nieminen et al., 2007; Nilsson and Cleveland, 2003; Peterson and Ayer, 2011; Prochownik, 2008; Ruggero, 2009; Secombe et al., 2004; Shchors and Evan, 2007; Singh and Dalton, 2009; van Riggelen et al., 2010).”
• MYC activation is a hallmark of cancer initiation and maintenance. (2014, background): “In particular, MYC suppression results in the permanent shutdown of genes related to ribosome biosynthesis and protein synthesis (Wu et al. 2008; van Riggelen et al. 2010b).”
• MYC on the Path to Cancer (2012, background): “It is long known that cancer cells are characterized by intense nucleolar hypertrophy; hence, a signature of cancer cells could now be linked mechanistically to Myc function (van Riggelen et al., 2010b).”
• THE HISTONE DEACETYLASE SIRT6 IS A NOVEL TUMOR SUPPRESSOR THAT CONTROLS CANCER METABOLISM (2012, positive): “As a master regulator of cell proliferation, MYC regulates ribosome biogenesis and protein synthesis by controlling the transcription and assembly of ribosome components as well as translation initiation (Dang et al., 2012; van Riggelen et al., 2010).”
• iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data (2018, background): “The 1570 upregulated genes contain 7 MYC target genes (FDR 4.22 × 10 − 7 ), consistent with the fact that MYC is a direct regulator of ribosome biogenesis [67].”