Mechanisms of caspase activation and inhibition during apoptosis.

By Yigong Shi. Molecules and Cells, 2002

1,864 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/63e201e0989478f1efb5a4204d888b7a9767a635

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Citations in the corpus

A unified model for apical caspase activation. (2003, background): “quired for catalytic activity (reviewed in Earnshaw et al., 1999; Salvesen and Dixit, 1997; Shi, 2002; Thornberry and Lazebnik, 1998).”
NOBEL LECTURE: Worms, Life and Death (2003, neutral): “, see [67, 70].”
Mechanisms of caspase activation. (2003, background): “Given the evidence that the active form of a caspase contains large and small subunits, it was assumed that all caspases were activated by proteolytic cleavage within their linker region (reviewed in [2]).”
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “These enzymes exist in most cells as inactive precursors (procaspases) that are converted into their active forms by proteolytic cleavage at internal aspartic acid residues, which separates the caspase into small and large subunits [167] and then they become”
Benefits of Dietary Butyric Acid, Sodium Butyrate, and Their Protected Forms in Aquafeeds: A Review (2020, background): “Apoptosis can be defined as programed cell death and involves noninflammatory fragmentation and phagocytosis of cells, which plays an important role in the growth and development of all multicellular organisms (Shi 2002).”
Autophagy: dual roles in life and death? (2005, background): “Caspase-8 and caspase-10 either directly activate effector caspases, such as caspase-3, or activate the mitochondrial apoptosis pathway, which involves BCL2 family members, cytochrome c release, and the formation and activation of the apoptosome (a complex that comprises caspase-9, apoptotic prote”
Caspases in apoptosis and beyond (2008, background): “Reproduced with permission from Shi (2002). (c) The active site conformations of the caspases with known structures.”
The Bcl2 family: regulators of the cellular life-or-death switch (2002, background): “To prevent unscheduled cell suicide, each caspase is synthesized as a pro-enzyme that typically requires processing at caspase cleavage sites to generate the active enzym”
Copper metabolism in cell death and autophagy (2023, background): “Apoptosis is a form of programmed cell death usually manifested by the externalization of phosphatidylserine and the activation of the endogenous caspases [73].”
Ways of dying: multiple pathways to apoptosis. (2003, background): “As illustrated in Figure 2, permeabilization of the outer mitochondrial membrane releases several cytotoxins (for review, see Wang 2001; Shi 2002), but whether any are essential for apoptosis is not yet established.”
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis (2013, background): “Effector caspases are responsible for initiating the hallmarks of the degradation phase of apoptosis, including DNA fragmentation, cell shrinkage and membrane blebbing [8,9].”
Validating survivin as a cancer therapeutic target (2003, background): “This mechanism has been elucidated in detail with respect to the kinetics of enzyme inhibition, assembly of IAP–caspase complexes and the structure–function requirements of caspase recognitio”
Mechanism of XIAP-mediated inhibition of caspase-9. (2003, background): “…apoptosis (IAP) family of proteins sup-370 Lancaster Avenue Haverford College presses apoptosis by inhibiting the enzymatic activity of both the initiator and the effector caspases (DeverauxHaverford, Pennsylvania 19041 3 Kimmel Cancer Center and Reed, 1999; Salvesen and Duckett, 2002; Shi, 2002b).”