Mechanisms of caspase activation.

By K. Boatright, G. Salvesen. Current Opinion in Cell Biology, 2003

1,448 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/235c4932cdb7720bbfe23f13687e6163c9ac4af4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Salvesen
2. S. Riedl
3. J. Tschopp
4. S. Fink
5. B. Cookson

In Epidemiology

1. J. Tschopp
2. Annick Mayor
3. Fabio Martinon
4. S. Riedl
5. B. Cookson
6. S. Fink
7. G. Salvesen

In Molecular Biology

1. J. Tschopp
2. Fabio Martinon
3. G. Salvesen
4. Annick Mayor
5. S. Fink
6. T. Kanneganti
7. F. Shao
8. S. Riedl

Citations in the corpus

• Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. (2020, background): “The downstream caspase-3/6/7 are intrinsic dimers but their activation also requires cleavage between the p20 and the p10 to adopt an active conformation (Boatright and Salvesen, 2003; Riedl andShi, 2004).”
• Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “The role of adapter proteins (FADD/TRADD) is to sequester, at level of this protein complex, the initiator pro-caspase-8 and/or -10 resulting in the formation of the so-called death-inducing signaling complex (DISC), increasing the local concentration of pro-caspase and promoting the mutual auto-act”
• Transcriptomic responses to heat stress and bleaching in the elkhorn coral Acropora palmata (2010, background): “This likely reflects previous findings that caspase-3, which is an executioner caspase, requires activation via post-translational modification (Boatright & Salvesen 2003).”
• The apoptosome: signalling platform of cell death (2007, background): “The contrasting hypotheses, including recent revisions of the models, have been reviewed extensivel”
• The inflammasomes: guardians of the body. (2009, background): “These platforms integrate cellular signals, recruit initiator caspases via their death-fold domain, and promote dimerization of the caspases, which all lead to the formation of an active enzyme proficient enough to initiate specific signaling cascades (74).”
• Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells (2005, background): “composed of two large subunits and two small subunits (6).”
• Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis (2012, background): “FADD recruits and induces dimerization and activation of the autocatalytic activation of the initiator cysteine proteases caspases 8 and 10, which drive apoptosis (11, 12).”