Caspases in apoptosis and beyond

By J. Li, Junying Yuan. Oncogene, 2008

1,018 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “Apoptosis is primarily executed by a family of proteases known as the caspases (cysteinyl, aspartate-specific proteases) [13].”
Apoptosis and cancer: mutations within caspase genes (2009, background): “dominant negative caspase-8 that leads to the formation of a signalling inactive DISC.(19)”
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration (2010, neutral): “of apoptosis [54].”
Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis (2015, background): “At present, 14 mammalian caspases have been identified, and they are classified into initiator caspases (caspases-2, -8, -9 and -10), effector caspases (caspases-3, -6 and -7) and the inflammatory caspases (caspases-1, -4, -5, -11, -12 and -13) (Table 1) [15,16].”
Cellular mechanisms controlling caspase activation and function. (2013, background): “Phenotypes of the caspase knockout mice have provided additional evidence to support a role for caspases in nonapoptotic processes (reviewed in Li and Yuan 2008).”