A unified model for apical caspase activation.

By K. Boatright, M. Renatus, F. Scott, S. Sperandio, Hwain Shin, I. Pedersen, J. Ricci, W. Edris, D. Sutherlin, Douglas R. Green and 1 more. Molecules and Cells, 2003

1,029 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d4560525b589680bcbd46e8d8445d7992e187591

How researchers see this paper

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In Cell Biology

1. S. Riedl
2. J. Tschopp
3. Jerry M. Adams
4. Yigong Shi
5. G. Salvesen
6. Fabio Martinon
7. Gunnar N. Schroeder
8. T. Mak

In Molecular Biology

1. J. Tschopp
2. G. Salvesen
3. Fabio Martinon
4. S. Riedl
5. Jerry M. Adams
6. K. Boatright
7. Zhaoyu Jin
8. T. Mak

Citations in the corpus

• Life and death in peripheral T cells (2007, background): “The activation of pro-caspase-8 is believed to follow an 'induced proximity' model in which high local concentrations and the favourable mutual orientation of pro-caspase-8 molecules at the CD95 DISC lead to their autoproteolytic activatio”
• Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion (2008, background): “Upon extra- or intracellular stimulation, initiator procaspases are recruited into multiprotein complexes, wherein they come in close proximity and become activated by autocatalytic proteolysis (26, 279).”
• The apoptosome: signalling platform of cell death (2007, methodology): “Activation of monomeric caspase-9 can be achieved in vitro by biochemically inducing dimerization using high concentrations of kosmotropic salts, a tool typically used to crystallize protein”