Mechanism of XIAP-mediated inhibition of caspase-9.

By E. Shiozaki, J. Chai, Daniel J. Rigotti, S. Riedl, Pingwei Li, S. Srinivasula, E. Alnemri, R. Fairman, Yigong Shi. Molecules and Cells, 2003

745 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4cfb01bdce862694c8e1536f0a9fe66da7ce668f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Riedl
2. Yigong Shi
3. G. Salvesen
4. Yang Zhang

In Epidemiology

1. Simone Fulda
2. S. Riedl
3. G. Salvesen
4. Yigong Shi

In Molecular Biology

1. G. Salvesen
2. Simone Fulda
3. D. Vučić
4. S. Riedl
5. Xiaoqiang Huang
6. F. Scott
7. Yigong Shi
8. Brendan P. Eckelman

Citations in the corpus

• Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “Structural studies have shown that inhibition of caspase 9 by XIAP involves the interaction of the peptide-binding groove of the BIR3 domain of XIAP with the N terminus of the small subunit p12 of processed caspase 9; this region contains a four-amino-acid IAP-binding sequence that is homologous to ”
• Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials (2020, background): “When the Smac released from the mitochondria, its N-terminal amino acids, alanine–valine–proline–isoleucine (AVPI) bind to the BIR3 domain of XIAP, which makes the XIAP lose the ability to combine with caspase, so as to promote apoptosis.96,97 Signal Transduction and Targeted Therapy (2020) 5:213 Th”
• Molecular mechanisms of caspase regulation during apoptosis (2004, background): “A mechanistic explanation for the inhibition of caspase-9 by XIAP was revealed by the crystal structure of caspase-9 bound to the BIR3 domain of XIAP (Ref”
• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family (2006, background): “Structural analysis of a BIR3/caspase-9 complex (Fig 3) showed that this distal helix packs against the dimer interface and monomerizes caspase-9, forcing the protease into an inactive conformation with a collapsed active site (Shiozaki et al, 2003).”
• Changing the Apoptosis Pathway through Evolutionary Protein Design (2019, background): “It should be mentioned that several studies have used the point mutation technique to identify the single mutants that may interfere the binding inter action of XIAP with caspase-9 [8,38,39].”
• Cellular mechanisms controlling caspase activation and function. (2013, background): “XIAP can inhibit caspase-3 and caspase-7 by binding to the active site, and caspase-9 by preventing or reversing dimerization (Deveraux et al. 1997; Chai et al. 2001; Riedl et al. 2001; Srinivasula et al. 2001; Shiozaki et al. 2003).”
• Promoting apoptosis as a strategy for cancer drug discovery (2005, background): “By contrast, XIAP-mediated inhibition of caspase 9 occurs by a different mechanis”