Mitochondria take center stage in aging and neurodegeneration
By M. Beal. Annals of Neurology, 2005
966 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/6385bdec028c23638a49120445b914fadb6f5a78
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Citations in the corpus
- Yeast Two-Hybrid, a Powerful Tool for Systems Biology (2009, neutral): “Systems bioenergetics holds the promise of integrating the multiple aspects of cellular energetics in a holistic approach which: (i) extends our knowledge on protein complexes involved in metabolic control and cell signalling [7], (ii) considers cellular compartmentation particularly important in th”
- Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. (2006, result): “Further, in addition to DNA damage caused by mutant APP and Ab that we observed, we also found increases in DNA damage corresponding to increases in the ages of the Tg2576 mice, supporting the widely accepted free-radical theory of aging in AD ( 21 ,22,44).”
- Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. (2008, background): “Oxidative stress was reported in the mitochondria of the brain, platelets, and fibroblasts from AD patients [48,49].”
- Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer’s Disease Brain Is Associated with Mitochondrial Dysfunction (2006, background): “Mitochondrial dysfunction is one of the earliest defects that has been detected in AD patients (Valla et al., 2001; Manczak et al., 2004; Beal, 2005).”
- The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “neurons [3–7].”
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “Accordingly, mitochondrial impairment has a great impact on neuronal function and survival (Nicholls & Budd, 2000; Kann & Kovács, 2007), and it is considered a key pathogenic player in several neurodegenerative and neurodevelopmental disorders (Fiskum, Murphy & Beal, 1999; Beal, 2005).”
- Neuronal calcium signaling: function and dysfunction (2014, background): “At the cellular level, PD is widely associated with defects in the respiratory chain complex I [202].”
- Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, neutral): “generative diseases [60–63].”
- Mitochondrial Dysfunction in Neurodegenerative Diseases (2012, background): “The ultimate cause of neuronal death and the debilitating phenotypes in ALS are currently unknown; however , several studies have reported mitochondrial damage and dysfunction in patients with ALS and SOD1 mutant transgenic mice (reviewed in Beal, 2005).”
- Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, result): “Mitochondrial dysfunction has been widely confirmed both in clinical and experimental studies of AD (Beal, 2005; Bubber et al., 2005; Lustbader et al., 2004; Schapira, 2012).”
- Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “However, we have focused initially on two neurodegenerative conditions since the connections between neurodegeneration and ROS are very strong (Beal, 2005; Schapira, 1998) and because there are well-established experimental systems to study these (Bove et al., 2005).”