Dynamic interplay between the collagen scaffold and tumor evolution

By M. Egeblad, Morten G. Rasch, Valerie M. Weaver. Current Opinion in Cell Biology, 2010

871 citations recorded by the source corpus.

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3444f760897a131cf2769fd5fb482a0bbf967c6f

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Citations in the corpus

The role of mechanical forces in tumor growth and therapy (2014, positive): “, metalloproteinases (MMPs) and lysil oxidase (LOX)) in order to increase matrix protein synthesis and crosslinking and decrease matrix proteinase activity (30-32), thereby increasing matrix stiffness (30).”
The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “This includes altered tissue mechanics, increased ECM rigidity due to collagen deposition and inflammation, and structural changes in the stem cell niche (51, 52).”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “Additionally, the tumor ECM contains increased amounts of collagens, PGs, and GAGs, especially hyaluronan and chrondroitin sulfate (122, 280, 391, 458, 525).”
The extracellular matrix modulates the hallmarks of cancer (2014, positive): “A critical aspect of the ECM is that it is dynamically remodeled and specifically tailored to the structure/function of each organ, and its composition, biomechanics and anisotropy are exquisitely tuned to reflect the physiological state of the tissue [4,5].”
Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “Type I collagen is the major structural protein in the interstitial ECM, while type IV is prevalent in basement membrane [68].”
Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “Consistent with these results, activation of collagen receptor DDR1 promotes macrophage infiltration in atherosclerotic plaques (Egeblad et al. 2010b).”
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “…primary tumors are complex heterogeneous tissues containing phenotypically and genetically distinct cancer cell subpopulations interacting with an altered extracellular matrix and diverse stromal cells (Almendro et al., 2013; Egeblad et al., 2010a, 2010b; Fidler, 2003; Weigelt and Bissell, 2008).”
Extracellular matrix: a dynamic niche component during cancer progression (2012, positive): “In contrast, interstitial matrix is rich in fibrillar collagens, proteoglycans, and various glycoproteins such as tenascin C and fibronectin and is thus highly charged, hydrated, and contributes greatly to the tensile strength of tissues (Egeblad et al., 2010b).”
Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “In addition to collagen type I, collagens type II, III, V, and IX all show increased deposition during tumor formation.(76) Increased collagen type V deposition, in particular, is mechanically significant, as it changes the structural organization of collagen type I fibrils.”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “Matrix proteolysis also results in the release of growth factors and cytokines, such as vascular endothelial growth factor (VEGF) and active TGF-β, that collectively provoke neo-angiogenesis and facilitate tumor cell intravasation (Egeblad et al., 2010b).”