Matrix metalloproteinases and tumor metastasis

By E. Deryugina, James P. Quigley. Cancer Metastasis Review, 2006

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Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “Indeed, secreted MMPs (MMPs-1, -2, -3, 7-, -8, -9, -10, -11, -13) as well as membrane-bound MT-MMPs are critical for the formation of cancer metastases, their invasion into the brain, and the formation of secondary tumors, and MMPs participate in most of the steps of the metastasis process (Figure 7”
Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “MMPs are involved in several stages of metastasis, including the escape of individual tumor cells from the primary tumor, their intravasation, extravasation, and establishment of tumor foci at secondary sites [125].”
Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “In fact, measurements of the partial pressure of oxygen in tumours reveal that poorly oxygenated tumours strongly correlate to increased malignancy [173].”
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “The most important physiological inhibitors of MMP function are the tissue inhibitors of metalloproteinases (TIMPs), which are also commonly expressed in tumor sites (Deryugina and Quigley, 2006).”
Contribution of platelets to tumour metastasis (2011, background): “In subsequent steps of the metastatic cascade, this high-affinity receptor further promotes tumour cell invasion by enhancing protease activatio”