TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression

By Yoko Katsuno, Samy Lamouille, R. Derynck. Current Opinion in Oncology, 2013

782 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1385eee1d71a171655597b50686b49325e299e55

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Fazlul H. Sarkar
2. Asfar S. Azmi
3. Y. Fouad
4. J. Tsai
5. K. Yeung
6. Jing Yang
7. C. Aanei
8. Bin Bao

In Molecular Biology

1. K. Yeung
2. Jing Yang
3. D. Sheppard
4. Fazlul H. Sarkar
5. Kevin K. Kim
6. Asfar S. Azmi
7. Y. Fouad
8. J. Tsai

In Oncology

1. K. Yeung
2. Jing Yang
3. D. Sheppard
4. Fazlul H. Sarkar
5. Kevin K. Kim
6. Asfar S. Azmi
7. Y. Fouad
8. J. Tsai

Citations in the corpus

• Epithelial–mesenchymal transition in tumor metastasis (2016, background): “Tumor growth factor beta (TGF-b), a cytokine secreted by tumor cells and stromal fibroblasts in the tumor microenvironment, is considered a primary inducer of EMT (Katsuno et al., 2013).”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “The hypoxic environment (a niche within tumor) is recognized to harbor cells that are drug resistant (compared with the bulk of the tissue) carrying markers that are reminiscent of EMT (a hall mark of cancer stem like cells as discussed in detail later) [160].”
• Revisiting the hallmarks of cancer. (2017, positive): “Take transforming growth factor-β (TGF-β) as an example, this conventional anti-growth ligand has been conversely shown to be implicated in tumorprogression both by stimulating cancer-cell dedifferentiation [22] and reshaping the TME [23].”
• TGF-β1 Signaling and Tissue Fibrosis. (2018, background): “TGF-b clearly elicits a phenotypic response in many cell types that might be viewed as an “activated” state (Katsuno et al. 2013; Derynck et al. 2014; Lamouille et al. 2014).”
• Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “Most notably, the TGF-b pathway appears to be a primary inducer of EMT (Katsuno et al. 2013).”
• Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration (2015, background): “The TGF-β pathway has been reported to be able to induce EMT [7,51], but other pathways are also involved in EMT including Wnt, Notch and PI3K-AKT pathways [52–56].”