Chemotaxis in cancer

By E. Roussos, J. Condeelis, A. Patsialou. Nature Reviews. Cancer, 2011

901 citations recorded by the source corpus.

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis. This Review summarizes how chemotaxis directs the different behaviours of tumour cells and stromal cells in vivo, how molecular pathways regulate chemotaxis in tumour cells and how chemotaxis choreographs cell behaviour to shape the tumour microenvironment and to determine metastatic spread. The central importance of chemotaxis in cancer progression is highlighted by discussion of the use of chemotaxis as a prognostic marker, a treatment end point and a target of therapeutic intervention.

Subfields: Immunology and Allergy, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4df92c0a96385fec434cc5cf52db546464c90c8f

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In Immunology and Allergy

In Molecular Biology

In Oncology

Citations in the corpus

The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “For a recent review on chemotaxis in cancer, see Roussos et al. (2011).”
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function (2012, background): “Cell-cell communication and chemotaxis (5) are key to this process and can occur via paracrine signals and/or direct contact between different cell types during tumor cell invasion (6) and metastatic colonization (7).”
Differential Macrophage Programming in the Tumor Microenvironment (2012, positive): “Migration on and through ECM is a necessary aspect of cell migration [72], and thus by extension, TAMs are thought to regulate tumor and stromal cell migration/invasion through ECM.”