A core Klf circuitry regulates self-renewal of embryonic stem cells

By Jianming Jiang, Yun-Shen Chan, Yuin Han Loh, Jun Cai, G. Tong, Ching-Aeng Lim, Paul Robson, Sheng Zhong, Huck-Hui Ng. Nature Cell Biology, 2008

788 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7607a82f4c45930d9d384591a33f863db92ca617

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Citations in the corpus

Nonequilibrium physics in biology (2019, background): “…activating genes mutually repressing each other (Ashwin and Sasai, 2015; Chickarmane and Peterson, 2008; Feng and Wang, 2012; Huang et al., 2009; Jiang et al., 2008; Li and Wang, 2013, 2014b, 2015; Sasai et al., 2013; Wang et al., 2010b, 2011; Xu et al., 2014b), such as PU.1GATA1 gene pair for…”
The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo (2013, background): “Prdm14 binding sites in embryonic stem cells (ESCs) substantially overlap those occupied by Nanog and Oct4, in keeping with its ability to protect ESCs from entering extraembryonic endoderm fates and ensure pluripotency (24).”
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010, result): “Our findings further support previous observations implicating regulation of the KLF transcriptional circuitry in establishing and maintaining naïve pluripotency (10, 11, 39, 40).”
Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “For example, in ES cells, KLFs 2, 4, and 5 all bind and activate Esrrb, Fbxo15, Nanog, and Tcl1 (198).”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “…and a draft of the core regulatory circuitry by which these factors exert their regulatory effects on protein-coding genes has been described (Boyer et al., 2005; Loh et al., 2006; Lee et al., 2006; Boyer et al., 2006; Jiang et al., 2008; Cole et al., 2008; Kim et al., 2008; Tam et al., 2008).”
Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “Klf4 has been implicated in ES cell self-renewal (Jiang et al., 2008; Li et al., 2005).”
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes (2013, positive): “…and Esrrb, which have previously been shown to play important roles in the ESC gene expression program and in reprogramming of somatic cells to iPS cells (Feng et al., 2009; Festuccia et al., 2012; Jiang et al., 2008; Martello et al., 2012; Percharde et al., 2012; Takahashi and Yamanaka, 2006).”
Role of the murine reprogramming factors in the induction of pluripotency (2009, positive): “In ES cells, chromatin immunoprecipitation (ChIP) experiments have demonstrated that Klf4, Sox2, and Oct4 together with other ES-specific transcription factors such as Nanog often co-occupy target genes, including their own promoters, which suggests that they cooperate in regulatory feedback loops t”
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (2009, positive): “This circuitry includes OCT4, SOX2, and KLF4, which form self-regulatory networks and control a wide range of downstream genes (Boyer et al., 2005; Jiang et al., 2008).”
Control of Embryonic Stem Cell State (2011, neutral): “Many of these regulators have emerged from systems-level et al., 2008; Dejosez et al., 2010); 14 (Jiang et al., 2008; Niwa et al., 2009); 15 (Chia et al., 2010); 16 (Hu et al., 2009; Kagey et al., 2010); 17 (Fazzio et al., 2008; Hu et al., 2009; Kagey et al., 2010); 18 (Ding et al., 2009); 19 (Kim…”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “Klf4 and Myc TFs are reprogramming factors that are also implicated in the maintenance of the undifferentiated state of ES cells (Cartwright et al., 2005; Jiang et al., 2008).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, neutral): “The 3i/2i rat ES cells express Klf4, Stella (Pgc7, Dppa3), and Rex1 (Zfp42), which discriminate ES cells from EpiSCs (Jiang et al., 2008; Tesar et al., 2007).”