In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

By Marius Wernig, Alexander Meissner, Ruth K. Foreman, T. Brambrink, Manching Ku, K. Hochedlinger, Bradley E. Bernstein, R. Jaenisch. Nature, 2007

2,614 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/08e3bb1bdf5baa4f2f23583a56bd7986b5551945

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In Molecular Biology

Citations in the corpus

Strategies and new developments in the generation of patient-specific pluripotent stem cells. (2007, background): “Nanog-selected iPS cells are almost indistinguishable from ES cells in global gene expression (Okita et al., 2007), DNA methylation, and histone modification (Maherali et al., 2007; Wernig et al., 2007).”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “which are functionally similar to ES cells (Maherali et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007).”
Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells (2014, background): “…number of procedures such as somatic cell nuclear transfer (SCNT) into oocytes (Gurdon 1962; Wilmut et al. 1997) and the use of defined transcription factors to create induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka 2006; Maherali et al. 2007; Okita et al. 2007; Wernig et al. 2007).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “…factors (Oct4, Sox2, Klf4, and c-Myc) reprograms mouse fibroblasts to ES-like cells (called iPS cells)(Takahashi and Yamanaka , 2006), the quality of which is enhanced upon selection of cells that express endogenous Oct4 or Nanog (Maherali et al., 2007; Okita et al., 2007; Wernig et al., 2007b).”
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. (2008, background): “Mice, cell lines, retroviral vectors, cell culture, immunostainings, and blastocyst injections were previously described in detail (Wernig et al., 2007).”
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (2008, background): “The portion of cells expressing AP, SSEA1, or GFP increased in both reporter lines over time, consistent with our previous results (Wernig et al., 2007).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “Reprogramming of mouse and human somatic cells to a pluripotent state has been achieved by viral transduction of four transcription factors, OCT4, KLF4, SOX2, and c-MYC (Aasen et al., 2008; Dimos et al., 2008; Hockemeyer et al., 2008; Lowry et al., 2008; Maherali et al., 2008; Nakagawa et al., 2008;”