Foxp3 occupancy and regulation of key target genes during T-cell stimulation

By A. Marson, Karsten Kretschmer, G. Frampton, Elizabeth S. Jacobsen, J. Polansky, Kenzie D. MacIsaac, S. Levine, E. Fraenkel, H. von Boehmer, Richard A. Young. Nature, 2007

782 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/61397c26afbb85d4ac4f7d2f38d31b0c1b953dde

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In Immunology

Citations in the corpus

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, background): “and a requirement for NFAT in Foxp3-mediated transcription and suppressor functio”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, methodology): “Initial studies of Foxp3 target genes were undertaken using a combination of chromatin immunoprecipitation (ChIP) with mouse genome tiling array or promoter array analyses (145, 146).”
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses (2010, positive): “This sizable cluster of ‘‘Foxp3-amplified’’ genes includes those serving as hallmarks of Treg cells (CTLA4, CD25, and GITR) and playing important functional roles in their homeostasis and function (Gavin et al., 2007; Lin et al., 2007; Zheng et al., 2007; Marson et al., 2007).”
Regulatory T Cells and Foxp3 (2011, result): “This idea is not inconsistent with the results of the genomewide analyses of Foxp3 target genes in Treg cells or in Foxp3 transfected hybridoma T-cell line using chromatin immunoprecipitation (ChIP) combined with whole genome tiling or custom promoter-enhancer arrays, respectively (40, 41).”
Antibody distance from the cell membrane regulates antibody effector mechanisms (2017, background): “CD137 is expressed on resting Tregs and is upregulated following activation (63, 64); therefore, it may serve as a useful target for Treg deletion.”
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “Foxp3 coordinates a transcriptional program that results in the expression of genes important for the regulatory function of T reg cells and prevents their production of proinflammatory cytokine”
Regulatory T cells and immune tolerance. (2008, background): “…searches for Foxp3 target genes have shown that Foxp3 directly or indirectly controls hundreds (~700) of genes and binds directly to ~10% of them (Marson et al., 2007; Zheng et al., 2007 depletion of Dicer, an RNase enzyme required for processing double-stranded RNA, hampers thymic development…”
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. (2007, background): “, 2006), and lists of Foxp3-binding genomic loci generated by chromatin immunoprecipitation (Zheng et al., 2007; Marson et al., 2007).”
Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments (2017, background): “A previous study investigating the transcriptional profile of Foxp3 identified Foxp3 binding toNdufv2, which encodes nicotinamide adenine dinucleotide hydrate (NADH) dehydrogenase flavoprotein 2 and is part of ETC complex I (Marson et al., 2007).”
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007, background): “The transcription factor Foxp3 has been identified as crucial for the commitment of thymocytes to the T-reg lineag”
Foxp3 in control of the regulatory T cell lineage (2007, result): “In keeping with these results, two other studies also using Foxp3-transfected T cells or T cell lines reported changes in expression of Foxp3-binding genes ( Il2 , Ctla4 , Il2ra , Tnfsfr18 ) in a calcineurin-dependent fashion only upon TCR stimulatio”
A census of human transcription factors: function, expression and evolution (2009, background): “37 ) there have been 2,382 publications, including several ChIP–chip (chromatin immunoprecipitation coupled with microarray) studies exploring its genome-wide binding site”
An atlas of combinatorial transcriptional regulation in mouse and man (2010, positive): “…have been applied to map transcriptional networks in a variety of human cell types, including stem cells (Cole et al., 2008; Lee et al., 2006) and lymphocytes (Marson et al., 2007; Schreiber et al., 2006), and to characterize the binding motifs of many mammalian TF families (Berger et al., 2008).”