A census of human transcription factors: function, expression and evolution

By Juan M. Vaquerizas, Sarah K. Kummerfeld, Sarah A. Teichmann, Nicholas M. Luscombe. 2009

1,631 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Zhiping Weng
2. Tong Ihn Lee
3. Richard A. Young
4. Kevin Struhl

In Molecular Biology

1. Manolis Kellis
2. Heng Li
3. David Haussler
4. Richard A. Young
5. Wyeth W. Wasserman
6. Jason Ernst
7. Steven L. Salzberg
8. William Stafford Noble

Citations in the corpus

• Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “In total, HT-SELEX models now exist for 632 of the ~1400 (23) human TFs.”
• Ensembl 2019 (2018, background): “This new collection greatly expands our repertoire of known motifs and covers a significant fraction of all known transcription factors (27).”
• Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. (2010, methodology): “2001) encoding a human transcription factor (Vaquerizas et al. 2009), we mapped all matching DBD-containing Interpro entries.”
• Gene Ontology annotation of sequence-specific DNA binding transcription factors: setting the stage for a large-scale curation effort (2013, background): “Current estimates suggest that the human genome contains (cid:2) 1900 DbTF-coding genes (10).”
• Transcription factors and evolution: An integral part of gene expression (Review) (2020, neutral): “vertebrates, or metazoan and those found in most eukary‐ otes, including yeast (43).”
• Control of Embryonic Stem Cell State (2011, background): “In mammals, transcription factors make up the largest single class of proteins encoded in the genome, representing approximately 10% of all protein-coding genes (Levine and Tjian, 2003; Vaquerizas et al., 2009).”
• Transcription factors interact with RNA to regulate genes (2022, background): “C2H2 zinc finger, homeodomain, bHLH, bZIP) (Figure 1A) (Lambert et al., 2018; Vaquerizas et al., 2009).”
• iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections (2014, background): “The human genome encodes for about 1800 sequence-specific TFs, each of which regulates hundreds of target genes [1,4,5].”
• The effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking density (2014, neutral): “Transcription factors are key cellular molecules involved in regulating gene expression in response to biological and environmental stimuli (Sahin et al., 2010a; Vaquerizas et al., 2009).”