Signal transduction by tumor necrosis factor and its relatives.

By Véronique Baud, M. Karin. Trends in Cell Biology, 2001

1,718 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/60ccedb58873ad4e40999cfeee702070391cb4c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. M. Karin
5. Taro Kawai
6. K. Takeda
7. G. Hotamışlıgil
8. O. Takeuchi

In Immunology

1. Shizuo Akira
2. S. Ghosh
3. Taro Kawai
4. M. Karin
5. M. Hayden
6. O. Takeuchi
7. R. Medzhitov
8. K. Takeda

In Oncology

1. Shizuo Akira
2. M. Karin
3. Taro Kawai
4. O. Takeuchi
5. S. Ghosh
6. M. Hayden
7. T. Lawrence
8. K. Takeda

Citations in the corpus

• IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis (2003, background): “induction, each stimulus activates NFkB by a distinct mechanism (52, 53).”
• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. (2007, background): “While the TNF signaling cascade is divergent and can evoke multiple pathways, activation of the mitogen-activated protein kinases (JNK and p38) and formation of the transcription complexes of the AP-1 family and NF- B are common events (16).”
• Chronic Inflammation in Obesity and the Metabolic Syndrome (2010, background): “They exert powerful effects on proinflammatory gene expression, through activation of activator protein-1 (AP-1) complexes and NFκB [52].”
• Tumor necrosis factor signaling (2003, background): “tional activation of a huge number of inflammatory-related genes in response to cytokines, for example, TNF and IL-1, bacterial products and some forms of physical ‘stress’, for example, UV radiation or reactive oxygen species.(44) In the recent years, it became also evident that NF-kB induces a var”
• Adipocytokines in Obesity and Metabolic Disease (2014, neutral): “…(Park et al. 2010). http://joe.endocrinology-journals.org DOI: 10.1530/JOE-13-0339 2014 Society for Endocrinology Printed in Great Britain TNFa exerts its effects through two distinct receptors, p55 and p75, which further activate JNK1 and inhibit IkB kinase(IKK)/NFkB pathways (Baud & Karin 2001).”
• Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. (2010, background): “In these enhancers, binding sites for the lineage-restricted and constitutive Ets protein PU.1 coexisted with those for ubiquitous stress-inducible transcription factors such as NF-kB, IRF, and AP-1.”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “Reactive oxygen species have been implicated as second messengers involved in the activation of NF- B via tumour necrosis factor (TNF) and interleukin-1 (Baud & Karin, 2001).”
• Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved (2007, background): “It is a pleiotropic cytokine with widespread effects on cellular responses such as cell proliferation and differentiation, apoptosis, and immunity and inflammation (Baud and Karin, 2001).”
• Inflammation and metabolic disorders (2006, background): “These kinases also exert powerful effects on gene expression, including promoting further inflammatory gene expression through activation of activator protein-1 (AP-1) complexes and NF-κ”