Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function.

By Francis G. Spinale. Physiological Reviews, 2007

1,136 citations recorded by the source corpus.

Subfields: Cancer Research, Cardiology and Cardiovascular Medicine, Oncology

View Paper: https://www.semanticscholar.org/paper/e45cfd17dc13d8bca143d456a84a293c552f5d19

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In Cancer Research

1. Yide Cao
2. W. Qin
3. Xin Chen
4. Wen Chen
5. Liangpeng Li
6. A. Takawale
7. Z. Kassiri
8. Nikolaos G. Frangogiannis

In Cardiology and Cardiovascular Medicine

1. Nikolaos G. Frangogiannis
2. Yide Cao
3. Joseph A. Hill
4. W. Qin
5. Xin Chen
6. Wen Chen
7. Liangpeng Li
8. A. Takawale

In Oncology

1. Yide Cao
2. W. Qin
3. Xin Chen
4. Wen Chen
5. Liangpeng Li
6. A. Takawale
7. Z. Kassiri
8. Nikolaos G. Frangogiannis

Citations in the corpus

• Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. (2012, background): “Significant alterations in the structure and composition of the extracellular matrix contribute to the development of heart failure [100].”
• Cellular Mechanotransduction: From Tension to Function (2018, background): “Following a cardiovascular event (ischemic insult, long term exposure to pressure or volume overload), cardiac matrix is degraded and substituted by a scar, having a different nanostructure and compliance (Spinale, 2007).”
• Cardiac fibrosis. (2020, background): “Resident cardiac fibroblasts may serve to maintain the structural integrity of the matrix network,(16) regulating collagen turnover, a process that requires ongoing synthesis and degradation of ECM proteins.(17,18) Fibroblast-specific baseline activation of Smad3 signal-”
• Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 (2013, background): “This surplus extracellular matrix, which constitutes scar or fibrosis, promotes both contractile dysfunction and rhythm disturbances.(84) As a result, cardiac fibrosis contributes to morbidity and mortality in many forms of heart disease.”
• The Pathogenesis of Cardiac Fibrosis (2013, neutral): “Homeostatic control of the cardiac extracellular matrix involves ongoing synthesis and degradation of matrix proteins [17, 18].”
• Upregulation of ADAMTS-7 and downregulation of COMP are associated with aortic aneurysm (2017, positive): “A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), belonging to the metalloproteinase family, is important in bone formation and arterial/cardiac remodeling (2-4).”
• Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease (2012, background): “Among the 26 MMPs cloned and characterized in vertebrates, the MMPs so far identified to be involved in myocardial remodeling are as follows: MMP1, MMP3, MMP8, MMP13, MMP2, MMP9, MMP12, MMP28 and the membrane-type MMPs (MT1-MMP/MMP14) [65-69], although the role of higher MMPs in the cardiovascular s”