Adipocytokines in Obesity and Metabolic Disease
By Haiming Cao. Journal of Endocrinology, 2014
648 citations recorded by the source corpus.
The current global obesity pandemic is the leading cause for the soaring rates of metabolic diseases, especially diabetes, cardiovascular disease, hypertension and non-alcoholic hepatosteatosis. Efforts devoted to find cures for obesity and associated disorders in the past two decades have prompted intensive interest in adipocyte biology, and have led to major advances in the mechanistic understanding of adipose tissue as an essential endocrine organ. Adipose tissue secretes an array of hormones (adipokines) that signal key organs to maintain metabolic homeostasis, and their dysfunction has been causally linked to a wide range of metabolic diseases. In addition, obesity induces production of inflammatory cytokines (often referred to together with adipokines as adipocytokines) and infiltration of immune cells into adipose tissue, which creates a state of chronic low-grade inflammation. Metabolic inflammation has been increasingly recognized as a unifying mechanism linking obesity to a broad spectrum of pathological conditions. This review focuses on classic examples of adipocytokines that have helped to form the basis of the endocrine and inflammatory roles of adipose tissue, and it also details a few newly characterized adipocytokines that provide fresh insights into adipose biology. Studies of adipocytokines in clinical settings and their therapeutic potential are also discussed.
Subfields: Epidemiology, Pharmacology, Physiology
View Paper: https://www.semanticscholar.org/paper/97360510859bedddd26b16f0597a8ebf890c87f8
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Citations in the corpus
- Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “These molecules include adipose-derived hormones (known as adipokines) (Cao, 2014; Choi and Cohen, 2017; Stern et al., 2016), signaling lipids (Cao et al., 2008; Lynes et al., 2017; Stanford et al., 2018; Yore et al., 2014), inflammatory mediators (Brestoff and Artis, 2015; Glass and Olefsky, 2012;…”
- Obesity in autoimmune diseases: not a passive bystander. (2014, background): “These include classical cytokines such as interleukin (IL)-6 and Tumor Necrosis Factor alpha (TNFα), and specific molecules such as leptin and adiponectin [13].”