A multigenic program mediating breast cancer metastasis to bone.

By Yibin Kang, P. Siegel, Weiping Shu, M. Drobnjak, Sanna M. Kakonen, C. Cordon-Cardo, T. Guise, J. Massagué. Cancer Cell, 2003

2,625 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5fd740b30233ed0b69c1c95e39213fa77d36b804

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Massagué
2. D. Nguyen
3. A. Moustakas
4. C. Heldin
5. J. Talmadge
6. I. J. Fidler
7. Zena Werb
8. Aviv Regev

In Oncology

1. J. Massagué
2. R. Weinberg
3. D. Nguyen
4. Zena Werb
5. J. Talmadge
6. I. J. Fidler
7. K. Pantel
8. V. Plaks

Citations in the corpus

• Metastasis: from dissemination to organ-specific colonization (2009, background): “Although an awareness of this ability has prompted a quest to identify the genes that support metastasis to particular organ”
• TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. (2005, methodology): “We assessed the expression of these genes with RT-PCR (Figures 5, A and B, and 7A; unpublished results for Tgif; and Kowanetz et al. (2004) for Idb3).”
• The logic of TGFβ signaling (2006, background): “least two of these genes, IL11 and CTGF, are responsive to TGFb [96,105] (Fig.”
• New signals from the invasive front (2006, background): “Combinatorial expression of these genes induces bone metastasis in cells that would not otherwise colonize bon”
• Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003, background): “cgi?l=1490">CTGF ) in both epithelial cells and fibroblast”
• Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. (2014, methodology): “to Breast Cancer Cells Regulates”
• Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “…requirements for metastatic colonization is illustrated by the minimal overlap between genes identified as candidate mediators of the metastatic colonization of breast cancer cells in bone, lung, brain, or liver (Kang et al., 2003; Minn et al., 2005; Bos et al., 2009; Tabariès et al., 2011).”
• TGFβ in Cancer (2008, background): “Follistatin overexpression is implicated in hepatocarcinogenesis (Rodgarkia-Dara et al., 2006) and breast cancer bone metastasis (Kang et al., 2003b).”
• Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis (2006, background): “As specific primary tumours are composed largely of cells with a genetic make-up that compels them to metastasize, copious numbers of target molecules (such as the small GTPase, Rho C and the transcription factor,Twist) have been identified using gene expression profilin”
• Metastatic patterns in adenocarcinoma (2006, background): “microarrays, are providing a better understanding of the metastatic process at the molecular level.(7,8) The seed-and-soil hypothesis seemingly is challenged by”
• TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. (2008, positive): “Cell Culture and Reagents MDA-MB-231 and its metastatic derivatives LM2-4175 and BoM-1833 have been described previously (Kang et al., 2003b; Minn et al., 2005).”