Metastasis: from dissemination to organ-specific colonization

By D. Nguyen, Paula D. Bos, J. Massagué. Nature Reviews. Cancer, 2009

2,611 citations recorded by the source corpus.

Subfields: Aquatic Science, Nature and Landscape Conservation

View Paper: https://www.semanticscholar.org/paper/c258c9b8855fbc61fae34065f1854f2bc3acef18

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. R. Weinberg
2. J. Massagué
3. D. Hanahan
4. M. Karin
5. S. Grivennikov
6. Arthur W. Lambert
7. R. Derynck
8. F. Greten

Citations in the corpus

• Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis (2010, background): “Metastatic organotropism was investigated for breast cancer in a series of studies by identifying organ-specific metastasis gene signatures (34).”
• Antiangiogenic therapy: impact on invasion, disease progression, and metastasis (2011, background): “A change in the seed, the soil, or both? Although acquired drug resistance is an accepted reality for antiangiogenic therapy, how would resistance lead to a tumor phenotype of increased invasion or metastasis? When a locally growing primary tumor progresses to form distant metastases, several ste”
• Interactions between cancer stem cells and their niche govern metastatic colonization (2011, background): “, the successful initiation of metastatic growth, a process termed ‘metastatic colonization’, is inefficient for many cancer types and is accomplished only by a minority of cancer cells that reach distant site”
• Guidelines for the welfare and use of animals in cancer research (2010, background): “Applications include studies of basic biological processes and of tissue pharmacokinetics and pharmacodynamic responses to treatment (Paulmurugan et al, 2002; Galbraith et al, 2003; Pillai et al, 2008; Tennant et al, 2009; Nguyen et al, 2009b).”
• Anoikis: an emerging hallmark in health and diseases (2012, background): “This ability has important implications in the metastatic process where cancer cells must survive and migrate in the absence of proper ECM contacts [75,76].”
• Circulating Tumor Cell Clusters are Oligoclonal Precursors of Breast Cancer Metastasis (2014, background): “The metastatic spread of breast cancer, typically to bone, lung, liver, and brain, accounts for the vast majority of cancer-related deaths (Nguyen et al., 2009).”
• Tumors as organs: complex tissues that interface with the entire organism (2010, neutral): “This is not simply because the cancer cells get trapped in the capillary network of the first organ that they encounter after dissemination; for example, prostate cancer almost exclusively metastasizes to bone and not the lungs (reviewed in Nguyen et al., 2009).”
• TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis (2019, background): “TGF-β induces metastasis to bone, liver, lung and other tissues of specific cancer types, such as breast, lung, gastric and prostate cancers (Figure 6A) [213].”
• Immunity, Inflammation, and Cancer (2010, background): “A variety of cytokines present in the tumor microenvironment, including TNF-a, IL-6, and epiregulin, can promote the survival of circulating metastatic seeds (Nguyen et al., 2009).”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “Arguably, the best-understood example to date involves the metastatic colonization of the bone, which has been documented in the case of the osteolytic metastases formed by breast cancers (Nguyen et al., 2009; Obenauf and Massague, 2015; Weilbaecher et al., 2011).”