TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.

By David Padua, X. Zhang, Qiongqing Wang, C. Nadal, W. Gerald, R. Gomis, J. Massagué. Cell, 2008

986 citations recorded by the source corpus.

Subfields: Cancer Research, Cardiology and Cardiovascular Medicine

View Paper: https://www.semanticscholar.org/paper/154defb0307164c70cbe6830756b87fc23bddaf4

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In Cancer Research

In Cardiology and Cardiovascular Medicine

J. Massagué

Citations in the corpus

EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “angiopoietin-like 4 (ANGPTL4), which enhances the permeability of the lung vasculature, promotes TEM of carcinoma cells, and leads to an increased capacity for metastatic outgrowth (Padua et al., 2008).”
TGFβ in Cancer (2008, methodology): “In breast cancer cells that have entered the pulmonary parenchyma, TGFβ may facilitate tumor reinitiation through an aberrant induction of ID1 expression (Padua et al., 2008).”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “Metastatic Colonization In the event that disseminated carcinoma cells survive their initial encounter with the microenvironment of a foreign tissue and succeed in persisting, they still are not guaranteed to proliferate and form large macroscopic metastases—the process of metastatic colonization.”
TGFβ signalling: a complex web in cancer progression (2010, background): “A recent study demonstrated that TGFβ in the breast cancer microenvironment primes cancer cells for pulmonary metastasi”
CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages (2009, background): “…carcinogenesis by virtue of their proangiogenic properties (Lin and Pollard, 2007), as well as foster pulmonary metastasis by providing epidermal growth factor (EGF) to malignant mammary epithelial cells (MECs) and thereby enhancing their invasive (and metastatic) behavior (Pollard, 2004).”
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. (2009, methodology): “…and Bottinger, 2005), as targets of LSD1/NuRD complexes and the well-documented roles of TGFb1 in breast cancer metastasis (Massague, 2008; Massague et al., 2000; Padua et al., 2008; Welch et al., 1990; Yang et al., 2008) suggest that LSD1 may also function in breast cancer invasion and metastasis.”
Latent bone metastasis in breast cancer tied to Src-dependent survival signals (2009, methodology): “The activity of seven signaling pathways was assessed in a cohort of 615 human breast tumors based on previously defined gene expression signatures (Bild et al., 2006; Padua et al., 2008; van de Wetering et al., 2002).”
Metastasis: from dissemination to organ-specific colonization (2009, background): “The basement membrane is an obstacle that circulating tumour cells can bypass only by expressing specific mediators of transendothelial migratio”