Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

By M. Boelens, Tony J. Wu, B. Nabet, Bihui Xu, Yu Qiu, T. Yoon, Diana J Azzam, Christina Twyman-Saint Victor, B. Wiemann, Hemant Ishwaran and 4 more. Cell, 2014

755 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0d3e511bb573390819ed74057013265aaa905cb9

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Citations in the corpus

The biology, function, and biomedical applications of exosomes (2020, positive): “When tumors are treated with radiation therapy or gamma secretase inhibitor, the expansion of tumor-initiating cells resistant to radiation therapy emerges through CAF-derived exosomal RNA and transposable elements transfer to cancer cells (174).”
Exosome-Based Cell-Cell Communication in the Tumor Microenvironment (2018, background): “And, finally, exosomal RNA produced by stromal cells were shown to activate RIG-I anti-viral signaling in breast cancer cells, leading to the expansion of therapy resistant breast cancer cells in a mechanism involving NOTCH3 induction (Boelens et al., 2014).”
The biology and function of exosomes in cancer. (2016, background): “Transfer of fibroblast-derived exosomes to breast cancer cells may confer chemotherapy and radiation therapy resistance via activation of STAT1-dependent antiviral signaling and NOTCH3 signaling in cancer cells (83).”
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “Previous studies reported that exosomes were transferred from stromal to breast cancer cells and contributed to drug and radiation resistance [57].”
Mechanisms of mesenchymal stem/stromal cell function (2016, background): “[178] reported cross-talk between stromal cells and breast cancer cells whereby stromal exosomes induced paracrine antiviral signals and stimulated juxtacrine Notch3 signaling that increased the number of therapy-resistant tumor-initiating cells.”
Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “…colleagues demonstrated that exosomal RNA from stromal cells can be transferred to breast cancer cells, activating NOTCH3 as well as STAT1-dependent antiviral signaling in these cancer cell resulting in the expansion of cancer cells resistant to chemotherapy and radiation (Boelens et al., 2014).”
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity (2020, background): “A series of recent studies indicate that some of these endogenous RNAP III transcripts can function as damage-associated molecular patterns (DAMPs), which are recognized by RIG-I (Boelens et al. 2014; Nabet et al. 2017; Chiang et al. 2018; Zhao et al. 2018).”
Exosomes in cancer: small particle, big player (2015, background): “suggest that exosomes transferred from stromal cells to breast cancer cells constitute a juxtacrine NOTCH3 pathway to expand therapy-resistant tumor-initiating cells [70].”