Metastatic patterns in adenocarcinoma

By K. Hess, G. Varadhachary, Sarah H. Taylor, Wei Wei, M. Raber, R. Lenzi, J. Abbruzzese. Cancer, 2006

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Metastasis: from dissemination to organ-specific colonization (2009, background): “Adenocarcinomas of the breast and lung typically relapse within a similar range of organs, including bone, lung, liver and brai”
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “Even if diagnosed at an early stage and surgically removed, lung adenocarcinomas can relapse within months, spreading to the lymph nodes, contralateral lung, adrenal glands, the bones, and the brain (Feld et al., 1984; Hess et al., 2006; Martini et al., 1995).”
Interactions between cancer stem cells and their niche govern metastatic colonization (2011, background): “Prevalent target sites are characteristic of many tumour entitie”
Treating metastatic cancer with nanotechnology (2011, background): “The majority of clinically detectable prostate metastases and breast metastases are present in the bone, suggesting that the bone has an active role in cancer cell recruitment, survival and outgrowt”