Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

By Sachie Hiratsuka, A. Watanabe, H. Aburatani, Y. Maru. Nature Cell Biology, 2006

1,033 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/767e1067536ac392e3b417f44c16912053ce3faf

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In Immunology

In Molecular Biology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “VEGFA, TGF-β, and tumor necrosis factor-α (TNF-α) produced by tumor cells trigger the expression of S100 chemokines by lung endothelium, which, in turn, mediate the directed migration of myeloid cells to these distant sites (Hiratsuka et al., 2006).”
Genetic determinants of cancer metastasis (2007, background): “Contributions by factors that are secreted from the metastatic microenvironment are also possibl”
Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “Neutralization of these factors with specific antibodies blocked the infiltration of Mac1 myeloid cells and the migration of cancer cells from primary tumors to the lung [85], suggesting that the S100A8 and S100A9 proteins could play a critical role in the formation of the pre-metastatic niche.”
Effect of Compassion Meditation on Neuroendocrine, Innate Immune and Behavioral Responses to Psychosocial Stress (2008, background): “Innate immune inflammatory signaling pathways are increasingly implicated in the pathogenesis of vascular disease (Willerson and Ridker, 2004), cancer (Aggarwal et al., 2006; Hiratsuka et al., 2006), diabetes (Pradhan et al.”
The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Finally, the chemoattractants S100A8 and S100A9 have also been shown to attract monocytes into lung adenocarcinom”
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche (2009, methodology): “The recruitment of CD11b+ myeloid cells to premetastatic sites may be influenced by VEGF-A and by the TGF-b and/or TNF-a pathways (Hiratsuka et al., 2006).”
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “Tumor-derived hypoxia-induced lysyl oxidase, VEGF, S100A8/A9, IL-6, and IL-10 (via activation of the S1PR1/STAT3 axis in the lungs) have all been implicated in the recruitment and activation of MDSCs in the lungs and the establishment of the premetastatic niche (42–44).”