New signals from the invasive front

By Gerhard Christofori. Nature, 2006

1,012 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4766c17c2c22a2a1f8a2029b1709da8c50ff133d

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In Molecular Biology

In Oncology

Citations in the corpus

Metastasis: from dissemination to organ-specific colonization (2009, background): “jpg" NDATA ITEM> ]> Tumour progression towards metastasis is often depicted as a multistage process in which malignant cells spread from the tumour of origin to colonize distant organ”
Distribution and biological activities of the flavonoid luteolin. (2009, background): “From a therapeutic point of view, invasion and metastasis are the most relevant processes of tumorigenesis; it is estimated that approximately 90% of all cancer deaths occur in patients with metastatic disease [187].”
Preparing the "soil": the premetastatic niche. (2006, background): “elements of the complex multistep process of metastasis (3).”
Engineering tumors with 3D scaffolds (2007, background): “Invasive capacity and responsiveness to cytotoxic drugs Malignant transition of epithelial tumors is often accompanied by apparent changes in tumor cell morphology, altered surface-marker expression and invasion into the surrounding strom”
MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “The activities — motility, survival and proliferation — that occur in developing, injured and neoplastic tissues embody a biological programme that is defined as 'invasive growth”
Matrix MetalloProteinases (MMPs) andTissue Inhibitors of MetalloProteinases (TIMPs): positive and negative regulators intumor cell adhesion (2010, neutral): “Genetic alterations, epigenetic signals, augmented proliferation, tumor inflammation and angiogenesis can elicit modified adhesive tumor cell behavior [4].”
Organizing the Cell Cortex: The role of ERM proteins (2010, background): “During the complex process of metastasis, tumour cells invade the surrounding normal tissue, recruit new blood vessels and successfully travel to and colonize distant organ”
Genetic determinants of cancer metastasis (2007, background): “Recent reviews have comprehensively analysed the biological traits and steps of cancer metastasi”
Notch signaling mediates hypoxia-induced tumor cell migration and invasion (2008, background): “Increased cell motility and invasiveness are important consequences of hypoxia-induced EMT (5).”
A review on the dietary flavonoid kaempferol. (2011, background): “It is recognized that the metastatic spread of primary tumors accounts for approximately 90% of all cancer deaths; the process by which cells from a localized tumor invade adjacent tissues and metastasize to distant organs may therefore be the most clinically relevant process involved in carcinogene”