Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

By P. Siegel, J. Massagué. Nature Reviews. Cancer, 2003

1,105 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9390db1b43959f0a88a401aa02c650deb485601d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Massagué
2. A. Moustakas
3. M. Nieto
4. C. Heldin
5. J. Seoane
6. D. Wotton
7. R. Flavell
8. F. Giancotti

In Oncology

1. J. Massagué
2. M. Nieto
3. J. Seoane
4. A. Moustakas
5. C. Heldin
6. R. Flavell
7. D. Wotton
8. Shomyseh Sanjabi

Citations in the corpus

• TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. (2008, neutral): “Additionally, TGFβ has potent inhibitory effects on cell proliferation and, as such, it can deter tumor growth (Bierie and Moses, 2006; Dumont and Arteaga, 2003; Siegel and Massagué, 2003).”
• Snail blocks the cell cycle and confers resistance to cell death. (2004, background): “Interestingly, TGF-␤ has multiple effects on cellular behavior, from inducing growth arrest and death to triggering EMT, survival, and tumor progression (Siegel and Massagué 2003).”
• Non-Smad TGF-β signals (2005, background): “TGF-β induces several genes that encode major constituents of the extracellular matrix and matrix regulatory enzymes (reviewed by Siegel and Massagué, 2003; Schiller et al., 2004), including plasminogen activator inhibitor 1 (PAI-1), collagenase I and the collagens (Dennler et al., 1998; Qing et…”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, methodology): “Another filtering approach used to further refine genomic profiles has been the comparisons of copy number alterations across different cancer types (Signoretti et al. 2000; Adsay et al. 2004; Garraway et al. 2005; Tonon et al. 2005).”
• MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, background): “In addition, DAXX has been implicated as a mediator of TGF-h apoptotic signals by virtue of its physical association with TGF-h receptor II/III (TGFBR2/3) and its requirement for TGF-h–induced apoptosis (27).”
• Smad transcription factors. (2005, background): “The repression of c-Myc in the context of the TGF cytostatic response was the first major example of this type of effect (Siegel and Massagué 2003).”
• Integrin signalling during tumour progression (2004, background): “However, many carcinomas eventually acquire mutations that render them insensitive to the growth-inhibitory action of TGF-&beta”