Cross-presentation, dendritic cells, tolerance and immunity.

By W. Heath, F. Carbone. Annual Review of Immunology, 2001

998 citations recorded by the source corpus.

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Citations in the corpus

Regulation of T cell immunity by dendritic cells. (2001, background): “There is increasing evidence thatMaturation transiently increases synthesis and transport of MHC class II molecules, while decreasing their degra- this presentation pathway leads to T cell deletion and to peripheral tolerance (Heath and Carbone, 2001).”
Tolerance and Exhaustion: Defining Mechanisms of T cell Dysfunction (2013, positive): “T cell fate following peripheral encounter with self-antigen is partly dictated by the activation state of the antigen-presenting cell (APC) [17,18]: T cells encountering selfantigen presented by non-activated or non-professional APCs receive incomplete priming signals, and either undergo programmed”
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines (2008, background): “Recognition of these peptide epitopes alone, in the absence of expression of co-stimulatory molecules, can tolerize Tc precursor”
Shaping and reshaping CD8+ T-cell memory (2008, background): “As a consequence of infection or immunization, DCs acquire foreign antigens and differentiate into mature antigen-presenting cells (APCs) that express co-stimulatory molecules, produce cytokines and migrate to secondary lymphoid organs to initiate responses from the rare, pathogen-specific CD8 + T ”
Dendritic cells: specialized and regulated antigen processing machines. (2001, neutral): “191, 435–444. eral tolerance (Heath and Carbone, 2001).”
Immunogenic and tolerogenic cell death (2009, background): “In addition, other studies have shown that antigens from apoptotic cells can be effectively cross-presented to cytotoxic T cells (CTLs) and prime an immune respons”
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon (2003, background): “However, bone marrow–derived APCs can also translocate antigens from the endocytic to the cytosolic compartment of the cell and thereby direct endocytosed proteins into the MHC class I presentation pathway, a process known as cross-presentatio”
Mouse and human dendritic cell subtypes (2002, background): “However, not all self-reactivity is eliminated from the T-cell receptor repertoire by central toleranc”
ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells (2003, background): “Peptides derived from phagocytosed antigens are then presented to CD8 p T lymphocytes on major histocompatibility complex (MHC) class I molecules, a process called “cross-presentation&rdquo”
Cancer immunotherapy via dendritic cells (2012, positive): “Non-activated (immature) DCs can present self-antigens to T cell”
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. (2002, background): “All three BM-derived APC, i.e., macrophages, DC, and B lymphocytes, have been reported to be competent to present class I-restricted exogenously derived antigens in vitro (for references see Heath and Carbone, 2001).”
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “This is the processing of captured proteins ontoMHC I without the need for synthesis in antigen-presenting cells (APCs) (Heath and Carbone, 2001).”
Viruses and their uses in nanotechnology (2006, background): “…[see review in Jondal et al., 1996; Rock, 1996], or (2) the endosome-to-cytosol pathway where the ingested antigenic particles are released from endosomes into the cytosol [Heath and Carbone, 2001] to be degraded by the proteasome complex [Huang et al., 1996; Kovacsovics-Bankowski and Rock, 1995].”