ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

By P. Guermonprez, L. Saveanu, M. Kleijmeer, J. Davoust, P. Endert, S. Amigorena. Nature, 2003

810 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/765dd90cb993499c61617a60684fe788c495d8eb

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In Immunology

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Citations in the corpus

• DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells (2005, background): “Phagosomes fuse with the endoplasmic reticulum in dendritic cells (24), suggesting that DC-STAMP may function in such a cytoplasmic membrane fusion.”
• Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “; the ability to fuse with the endoplasmic reticulum to generate hybrid compartment”
• NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, methodology): “…of beads was done to calculate the proportion of beads that are associated with but not phagocytosed by DCs. Phagosomes Purification DCs were incubated at indicated times with 3 mm magnetic latex beads and then disrupted in Homogenization Buffer as described (Guermonprez et al., 2003).”
• Matters Arising Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation (2005, background): “Even a small fractional contribution of the ER to the membrane of the phagosome is compatible with its proposed role in cross-presentation by MHC class I (Ackerman et al., 2003; Guermonprez et al., 2003; Houde et al., 2003).”
• In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination (2004, background): “This receptor may be specialized to target antigens to the exogenous pathway for antigen processing and presentation on MHC class I (20), which likely entails the fusion of elements of the rough endoplasmic reticulum with endocytic vesicles (38, 39).”
• Present Yourself! By MHC Class I and MHC Class II Molecules (2016, background): “The fragments may then be loaded on MHC I molecules in the ER or translocated back into the phagosome for local MHC class I peptide loading[78].”
• Phagosomes are competent organelles for antigen cross-presentation (2003, result): “Our results, and those presented in an accompanying pape”