Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

By A. L. Bon, N. Etchart, C. Rossmann, M. Ashton, S. Hou, D. Gewert, P. Borrow, D. Tough. Nature Immunology, 2003

912 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fbb5e2842ee73b5fbf5583af9e507fa0bb6abea3

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Citations in the corpus

Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens (2004, background): “This ability is clearly important for blocking viral replication, but it has also been reported to activate other DCs, including those involved in cross-priming (94).”
TLR3: interferon induction by double-stranded RNA including poly(I:C). (2008, background): “In many cases, virally infected cells produce IFN-α/β which activate DCs to promote CD8 T cell cross-priming [79].”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “…2005), or proinflammatory cytokines such as TNF-a or IL-6, may act by enhancing costimulatory molecules and immunogenicity of DCs themselves (Le Bon et al., 2003); they may also act directly on T cells to induce robust CD8+ T cell expansion (Kolumam et al., 2005) or bypass suppressor effects…”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “They also increase the ability of mDCs to cross-present exogenous antigens to CD8 + T cells and promote their clonal expansio”
Shared and Distinct Functions of Type I and Type III Interferons (2019, neutral): “…cell activation and cytotoxicity (e.g., NKp46 and class I MHC), and (5) inducing dendritic cells (DCs) to produce chemokines (e.g., CXCL9 and CXCL10) and cytokines (e.g., IL-15) that enhance cross-presentation and promote T cell proliferation and survival (Crouse et al., 2015; Le Bon et al., 2003).”
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “The presence of high levels of lesional IFN- might favor cross-presentation of sequestered tissue-specific autoantigens by myeloid DCs (47).”
Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1 (2005, background): “production by CD4 T cells (1), and effects on Ag-presenting dendritic cells (DC)(4) (2, 3).”
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells (2011, background): “But type I IFNs also regulate antiviral immune effector responses and play an important role in promoting the cross-presentation of viral antigens to CD8+ T cells (Le Bon et al., 2003).”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Production of IFN by infected cells can promote the maturation of DCs (Le Bon et al., 2003) and, whilst IFN http://vir.sgmjournals.org 15 Downloaded from www.microbiologyresearch.org by IP: 54.70.40.11 On: Thu, 06 Dec 2018 10:52:31 inhibits the proliferation of naı̈ve CD8+ T cells (Petricoin et…”