Dendritic cells: specialized and regulated antigen processing machines.

By I. Mellman, R. Steinman. Cell, 2001

2,484 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3a3dff65bcdf28b72d3ff2c43c9124f4a3cf8c6b

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In Immunology

Citations in the corpus

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease (2006, background): “Antigens on the surface of APCs are recognized either by CD4 or by CD8 T cells and they become fully activated only when receiving additional co-stimulatory signals from APCs.”
CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4 (2011, background): “See also Figure S1. directly to LPS (Wright et al., 1990), and is known to chaperone LPS molecules to the TLR4-MD-2 signaling complex (da Silva Correia et al., 2001; Gioannini et al., 2004; Moore et al., 2000).”
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “There have been major advances in understanding DC biology and function (Mellman and Steinman, 2001).”
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling (2014, neutral): “The data are plotted as the mean See also Figures S3, S4, and S5. the average total tumor burden at 2 months was 33 mm3 (Figure 5C), which was close to 10%of the total lung volume (Mitzner et al., 2001).”
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells (2011, background): “About 60% of 4sU-Seq (RNA-4sU) reads were uniquely mapped to the genome, and 65% of these mapped in pairs (average insert size of 699 bases ± 5746 SD), while 30% of the reads mapped to rRNA (Supplementary Table 4).”
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “These specializations of the endocytic pathway include the regulated transport of MHC molecules (Mellman and Steinman, 2001; Pierre et al., 1997), the transport of antigen from endosomes and phagosomes into the cytosol (Guermonprez and Amigorena, 2005), and the recruitment of ER proteins to…”