Autophagosome formation: core machinery and adaptations

By Zhiping Xie, D. Klionsky. Nature Cell Biology, 2007

2,248 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/15912c7c464a5ffd9afefb8ceb1f3c004cfe085b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. T. Johansen
3. Zhifen Yang
4. N. Mizushima
5. Ralph A. Nixon
6. T. Lamark
7. Y. Ohsumi
8. K. Guan

In Epidemiology

1. D. Klionsky
2. T. Johansen
3. T. Lamark
4. I. Slaninová
5. N. Mizushima
6. Zhifen Yang
7. Y. Ohsumi
8. Beth Levine

In Parasitology

1. D. Klionsky
2. Zhifen Yang
3. T. Lamark
4. Y. Ohsumi
5. T. Johansen
6. Zhiping Xie
7. Ivan Dikic
8. Kuninori Suzuki

Citations in the corpus

• Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system (2012, background): “In general, autophagy is mediated by specialized membranes that engulf cytoplasmic components and subsequently fuse with the lysosome for degradatio”
• Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates (2009, neutral): “The second involves conjugation of Atg8 to the lipid phosphatidylethanolamine, which is regulated by Atg7 along with Atg3 as the E2-like enzyme ( Xie and Klionsky, 2007 ).”
• Crosstalk between apoptosis, necrosis and autophagy. (2013, neutral): “3; [92,93]).”
• Autophagy as a target for anticancer therapy (2011, background): “The autophagy machinery The autophagic process is divided into several distinct phases that are controlled by the Atg (autophagy-related) family of proteins ( Table 1 )”
• Autophagy Failure in Alzheimer's Disease – Locating the Primary Defect (2011, background): “…cup-shaped omegasome, and sequesters a region of cytoplasm to form a double-membrane-limited autophagosome (Axe et al., 2008; Geng et al., 2010; Hailey et al., 2010; Hayashi-Nishino et al., 2009; Itakura and Mizushima, 2010; Ravikumar et al., 2010; Tian et al., 2010; Xie and Klionsky, 2007).”
• Dynamics and diversity in autophagy mechanisms: lessons from yeast (2009, background): “Thus, this protein has been extensively analysed to obtain insights into a membrane source of the autophagosom”
• Atg8 controls phagophore expansion during autophagosome formation. (2008, background): “Eukaryotic cells employ macroautophagy, hereafter referred to as autophagy, to eliminate objects ranging from soluble proteins to entire organelles (Yorimitsu and Klionsky, 2005; Xie and Klionsky, 2007).”
• Selective autophagy mediated by autophagic adapter proteins (2011, background): “Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process that involves the sequestration and transport of organelles and macromolecules to the lysosomes for degradation.(1,2) Following lysosomal degradation, recycling occurs to replenish the cell with nutr”
• Biology of Zika Virus Infection in Human Skin Cells (2015, background): “Autophagy not only participates in the degradation of proteins and damaged organelles in the cytoplasm to maintain homeostasis (49) but also is involved in host immunity against pathogen infection.”
• Nix is a selective autophagy receptor for mitochondrial clearance (2010, background): “Its main hallmark is the formation of double-membrane vesicles—autophagosomes—that engulf cargo and deliver it to lysosomes for degradation”
• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 (2011, background): “Genetic studies in Saccharomyces cerevisiae have defined the autophagy machiner”
• Selective autophagy: ubiquitin-mediated recognition and beyond (2010, background): “Although most of these components are common to autophagy and the Cvt pathway, autophagy-specific and Cvt-specific genes also exist, such as the Cvt-specific cargo receptor Atg19 (see below; reviewed in ref”
• Autophagy and autophagy-related proteins in cancer (2020, background): “There are three morphologically and mechanistically distinct types of autophagy in cells: macroautophagy, microautophagy and chaperone mediated autophagy [3], and usually macroautophagy is referred to as autophagy [4].”
• Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control (2014, methodology): “In HeLa cells, expression of Atg5, beclin-1 (a core component of the PI[3] K complex regulating autophagy) and Rab9 (implicated in an alternative autophagic pathway) were individually silenced using siRNA (Supplementary Fig S6B; Xie & Klionsky, 2007; Narendra et al, 2008; Nishida et al, 2009).”
• Mammalian autophagy: core molecular machinery and signaling regulation (2009, background): “Among these Atg proteins, one subset is essential for autophagosome formation, and is referred to as the “core” molecular machinery [5].”