Role of autophagy in cancer

By Robin Mathew, V. Karantza-Wadsworth, E. White. Nature Reviews. Cancer, 2007

2,595 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f9a66eeb4b75ed35a84a475f2f4e2141e7c09620

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Hanahan
2. R. Weinberg
3. Alec C. Kimmelman
4. R. Shaw
5. Xiaohua Li
6. Binyun Ma
7. Shi-kun He
8. E. White

In Epidemiology

1. Alec C. Kimmelman
2. E. White
3. R. Amaravadi
4. Chang S. Chan
5. J. Mehnert
6. Xiaohua Li
7. Binyun Ma
8. Shi-kun He

In Molecular Biology

1. D. Hanahan
2. R. Weinberg
3. Alec C. Kimmelman
4. R. Shaw
5. R. Amaravadi
6. Chang S. Chan
7. J. Mehnert
8. E. White

Citations in the corpus

• Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “Autophagy is a catabolic cellular mechanism that allows the cell to maintain a balance between the synthesis, degradation, and recycling of cellular products [109].”
• Autophagy, Metabolism, and Cancer (2015, positive): “The dependence of cancers on autophagy and exploration of the underlying mechanism suggests that maintenance of mitochondrial function is important for cancer (5).”
• Mitochondria and Cancer (2016, background): “Inhibiting autophagy and mitophagy can interfere with mitochondrial metabolism by blockingmitochondrial quality control and/or substrate supply (White, 2015; White et al., 2015).”
• Autophagy and multidrug resistance in cancer (2017, background): “Autophagy also plays dual roles in tumorigenesis, tumor progression, and resistance of cancer cells to chemotherapy [47].”
• Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates (2015, background): “It has been suggested that at the early stages of tumor formation the enhancement of autophagic flux may be therapeutically beneficial by clearing mutant or misfolded proteins and alleviating cellular stress (White, 2015).”
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. (2009, background): “Depending on the cellular context and the strength and duration of the triggering stimulus, autophagy is involved in the promotion or inhibition of cancer cell survival (4, 5, 24, 25).”
• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains (2009, background): “However, in the context of hypoxia, nutrient depletion, or growth factor deprivation, it is clear that autophagy is crucial in maintaining cellular ATP production and macromolecular synthesis and, therefore, represents an essential prosurvival pathway (19).”